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Roberts Lab: Publications

2017

  • Alver BH, Kim KH, Lu P, Wang X, Manchester HE, Wang W, Haswell JR, Park PJ, Roberts CW. The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers. Nat Commun Mar 6;8:14648, 2017. doi: 10.1038/ncomms14648. PMID: 28262751

  • Mathur R, Alver BH, San Roman AK, Wilson BG, Wang X, Agoston AT, Park PJ, Shivdasani RA, Roberts CW. ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice. Nat Genet Feb;49(2):296-302, 2017. doi: 10.1038/ng.3744. Epub 2016 Dec 12. PMID: 27941798

  • Wang X, Lee RS, Alver BH, Haswell JR, Wang S, Mieczkowski J, Drier Y, Gillespie SM, Archer TC, Wu JN, Tzvetkov EP, Troisi EC, Pomeroy SL, Biegel JA, Tolstorukov MY, Bernstein BE, Park PJ, Roberts CW. SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation. Nat Genet Feb;49(2):289-295, 2017. doi: 10.1038/ng.3746. Epub 2016 Dec 12. PMID: 27941797


2016

  • Kim KH, Roberts CWM. Targeting EZH2 in cancer. Nature Medicine 22: 128-34, 2016.

  • Harris MH, DuBois SG, Glade Bender JL, Kim A, Crompton BD, Parker E, Dumont IP, Hong AL, Guo D, Church A, Stegmaier K, Roberts CWM, Shusterman S, London WB, MacConaill LE, Lindeman NI, Diller L, Rodriguez-Galindo C, Janeway KA. Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors: The Individualized Cancer Therapy (iCat) Study. JAMA Oncol Jan 28, 2016. doi: 10.1001/jamaoncol.2015.5689.


2015

  • Kim KH, Woojin K, Howard TP, Vazquez F, Tsherniak A, Wu JN, Wang W, Haswell JR, Walensky LD, Hahn WC, Orkin SH, Roberts CWM. SWI/SNF-mutant cancers depend upon catalytic and non-catalytic activity of EZH2. Nature Medicine Dec;21(12):1491-6, 2015.

  • Yin J, Leavenworth JW, Li Y, Luo Q, Xie H, Liu X, Huan S, Yan H, Fu Z, Zhang LY, Zhang LT, Hao J, Wu X, Deng X, Roberts CWM, Orkin SH, Cantor H, Wang X. Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity. PNAS Dec. 14, 2015. [Epub ahead of print]

  • Fahiminya S, Witkowski L, Nadaf J, Carrot-Zhang J, Goudie C, Hasselblatt M, Lee RS, Gayden T, Roberts CWM, Biegel JA, Jabado N, Majewski J, Foulkes WD. Molecular analyses reveal close similarities between small cell carcinoma of the ovary, hypercalcemic type and atypical teratoid/rhabdoid tumor. Oncotarget  Dec 4, 2015. [Epub ahead of print]

  • Kim KH, Woojin K, Howard TP, Vazquez F, Tsherniak A, Wu JN, Wang W, Haswell JR, Walensky LD, Hahn WC, Orkin SH, Roberts CWM. SWI/SNF-mutant cancers depend upon catalytic and non-catalytic activity of EZH2. Nature Medicine 2015 (in press).

  • Alizadeh AA, Aranda V, Bardelli A, Blanpain C, Bock C, Borowski C, Caldas C, Califano A, Doherty M, Elsner M, Esteller M, Fitzgerald R, Korbel JO, Lichter P, Mason CE, Navin N, Pe'er D, Polyak K, Roberts CWM, Siu L, Snyder A, Stower H, Swanton C, Verhaak RG, Zenklusen JC, Zuber J, Zucman-Rossi J. Toward understanding and exploiting tumor heterogeneity.Nature Medicine 21(8): 846-853, 2015. PMID: 26248267.


2014

  • Perry JA, Kiezun A, Tonzi P, Van Allen EM, Carter SL, Baca SC, Cowley GS, Bhatt AS, Rheinbay E, Pedamallu CS, Helman E, Tailor-Weiner A, McKenna A, DeLuca DS, Lawrence  MS, Ambrogio L, Sougnez C, Sivachenko A, Walensky LD, Wagle N, Mora J, de Torres C, Lavarino C, dos Santos Aguiar S, Yunes JA, Brandalise SR, Mercado-Celis GE, Melendez-Zajgla J, Cárdenas-Cardós R, Velasco-Hidalgo L, Roberts CWM, Garraway LA, Rodriguez-Galindo C, Gabriel SB, Lander ES, Golub TR, Orkin SH, Getz G, Janeway KA. Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma. Proc Natl Acad Sci USA Dec 23;111:E5564-73, 2014. PMID: 25512523 PMCID: PMC4280630

  • Pugh TJ, Yu W, Yang J, Ambrogio L, Field A, Carter SL, Cibulskis K, Giannikopoulos P, Kiezun A, Kim J, McKenna A, Nickerson E, Getz G, Hoffner S, Messinger YH, Dehner LP, Roberts CWM, Rodriguez-Galindo C, Williams GM, Rossi CT, Meyerson M, Hill DA. Exome sequencing of pleuropulmonary blastoma reveals frequent biallelic loss of TP53 and two-hit DICER1 loss resulting in retention of 5p-derived miRNA hairpins. Oncogene Nov 6;33:5295-302, 2014. PMID: 24909177 PMCID: PMC4224628

  • Helming KC, Wang X, Wilson BG, Vazquez F, Haswell JR, Manchester HE, Kim Y, Kryukov, Ghandi M, Aguirre AJ, Jagani Z, Wang Z, Garraway LA, Hahn WC, Roberts CWM. ARID1B is a specific vulnerability in ARID1A-mutant cancers. Nature Medicine 20(3):251-4, 2014. PMID: 24562383 PMCID: PMC3954704

  • Hoffman GR, Rahal R, Buxton F, Xiang K, McAllister G, Frias E, Bagdasarian L, Huber J, Lindeman A, Chen D, Romero R, Ramadan N, Phadke T, Haas K, Jaskelioff M, Wilson BG, Meyer MJ, Saenz-Vash V, Zhai H, Myer VE, Porter JA, Keen N, McLaughlin ME, Mickanin C,Roberts CWM, Stegmeier F, Jagani Z. A functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers. Proceedings of the National Academy of Sciences USA 111(8): 3128-33, 2014. PMID: 24520176 PMCID: PMC3939885

  • Wilson BG, Helming KC, Wang X, Kim Y, Vazquez F, Jagani Z, Hahn WC, Roberts CWM. Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation. Molecular and Cellular Biology 34(6):1136-44, 2014. PMID: 24421395 PMCID: PMC3958034

  • Helming KC, Wang X, Roberts CWM. Vulnerabilities of mutant SWI/SNF complexes in cancer. Cancer Cell 26: 309-317, 2014. PMID: 25203320 PMCID: PMC4159614

  • Kim KH, Roberts CWM.  Mechanisms by which SMARCB1 loss drives rhabdoid tumor growth. Cancer Genetics 207:365-372, 2014. PMID: 24853101 PMCID: PMC4195815

  • Wang X, Haswell JR, Roberts CWM. SWI/SNF (BAF) complexes are frequently mutated in cancer: mechanisms and potential therapeutic insights. Clinical Cancer Research 20: 21-7, 2014. PMID: 24122795 PMCID: PMC3947303

  • Mora-Blanco EL, Mishina Y, Tillman EJ, Cho Y-J, Thom CS, Pomeroy SL, Shao W, Roberts CWM. Activation of b-catenin/TCF targets following loss of the tumor suppressor SNF5. Oncogene Feb 13;33:933-38, 2014. PMID: 23435428


2013

  • Wöhrle S, Weiss A, Ito M, Kauffmann A, Murakami M, Jagani Z, Thuery A, Bauer-Probst B, Reimann F, Stamm C, Pornon A, Romanet V, Guagnano V, Brümmendorf T, Sellers WR, Hofmann F, Roberts CWM, Graus Porta D. Fibroblast growth factor receptors as novel therapeutic targets in SNF5-deleted malignant rhabdoid tumors. PLoS One 8(10):e77652, 2013. PMID: 24204904 PMCID: PMC3813701

  • Tolstorukov MY, Sansam CG, Lu P, Koellhoffer EC, Helming KC, Alver BH, Tillman EJ, Evans JA, Wilson BG, Park PJ, Roberts CWM. Swi/Snf chromatin remodeling/tumor suppressor complex establishes nucleosome occupancy at target promoters. Proceedings of the National Academy of Sciences 110: 10165-70, 2013. PMID: 23723349 PMCID: PMC3690861

  • Lawrence MS, Stojanov P, Polak P, Kryukov GV, Cibulskis K, Sivachenko A, Carter SL, Stewart C, Mermel CH, Roberts SA, Kiezun A, Hammerman PS, McKenna A, Drier Y, Zou L, Ramos AH, Pugh TJ, Stransky N, Helman E, Kim J, Sougnez C, Ambrogio L, Nickerson E, Shefler E, Cortés ML, Auclair D, Saksena G, Saksena G, Voet D, Noble M, DiCara D, Lin P, Lichtenstein L, Jing R, Fennell T, Imielinski M, Hernandez B, Hodis E, Baca S, Dulak AM, Lohr J, Landau DA, Wu CJ, Melendez-Zajgla J, Hidalgo-Miranda A, Koren A, McCarroll SA, Mora J, Crompton B, Onofrio R, Parkin M, Winckler W, Ardlie K, Gabriel SB, Roberts CWM, Biegel JA, Stegmaier K, Bass A, Garraway LA, Meyerson M, Golub TR, Gordenin DA, Sunyaev S, Lander ES, Getz G. Mutational heterogeneity in cancer and the search for new cancer genes.Nature 499:214-8, 2013. PMID: 23770567 PMCID: PMC3919509

  • Kuwahara Y, Mora-Blanco EL, Banine F, Rogers A, Fletcher C, Sherman L, Roberts CWM, Weissman B. Establishment and Characterization of MRT Cell Lines from Genetically Engineered Mouse Models and the Influence of Genetic Background on Their Development.International Journal of Cancer 132:2767-77, 2013. PMID: 23197309 PMCID: PMC3605221

  • Lu P, Roberts CWM. The SWI/SNF tumor suppressor complex: Regulation of promoter nucleosomes and beyond.  Nucleus 4:374-378, 2013. PMID: 24145903 PMCID: PMC3899127

  • Lee RS, Roberts CWM. Rhabdoid tumors: an initial clue to the role of chromatin remodeling in cancer. Brain Pathology 23:200-5, 2013. PMID: 23432645
    Wu JN, Roberts CWM. ARID1A Mutations in Cancer:  Another Epigenetic Tumor Suppressor? Cancer Discovery 3:35-43, 2013. PMID: 23208470 PMCID: PMC3546152


2012

  • Kieran MW, Roberts CWM, Chi SN, Ligon KL, Rich BE, MacConaill LE, Garraway LA, and Biegel JA.  Absence of Oncogenic Canonical Pathway Mutations in Aggressive Pediatric Rhabdoid Tumors. Pediatric Blood and Cancer 59:1155-7, 2012. PMID: 22997201 PMCID: PMC3538080

  • Lee RS, Stewart C, Carter SL, Ambrogio L, Cibulskis K, Sougne C, Lawrence MS, Auclair D, Mora J, Golub TR, Biegel JA, Getz G, Roberts CWM. A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers. Journal of Clinical Investigation122:2983-2988, 2012. PMID: 22797305 PMCID: PMC3408754

  • McKenna ES, Tamayo P, Cho Y-J, Tillman EJ, Mora-Blanco EL, Sansam CG, Koellhoffer EC, Pomeroy SL, Roberts CWM.  Epigenetic inactivation of the tumor suppressor BIN1 drives proliferation of SNF5-deficient tumors. Cell Cycle 11:1956-65, 2012. PMID: 22544318 PMCID: PMC3359122


2011

  • Wang X, Werneck MBF, Wilson BG, Kim H-J, Kluk MJ, Thom CS, Wischhusen JW, Evans JA, Jesneck JL, Nguyen P, Sansam CG, Cantor H, Roberts CWM. T cell receptor dependent transformation of mature memory phenotype T cells in mice. Journal of Clinical Investigation121:3834-3845, 2011. PMID: 21926465 PMCID: PMC3195451

  • Wilson BG, Roberts CWM. SWI/SNF nucleosome remodelers and cancer. Nature Reviews Cancer 11:481-92, 2011.


2010

  • Jagani Z, Mora-Blanco EL, Sansam CG, McKenna ES, Wilson B, Chen D, Klekota J, Tamayo P, Nguyen PTL, Tolstorukov M, Park PJ, Cho YJ, Hsiao K, Buonamici S, Pomeroy SL, Mesirov JP, Ruffner H, Bouwmeester T, Luchansky S, Murtie J, Kelleher J, Warmuth M, Sellers WR,Roberts CWM*, Dorsch M(*Co-corresponding senior authors and contributed equally). Loss of the Tumor Suppressor Snf5 Leads to Aberrant Activation of the Hedgehog-Gli Pathway. Nature Medicine 16:1374-6, 2010. PMID: 21076395 PMCID: PMC3859448

  • Wilson BG, Wang X, Shen X, McKenna ES, Lemieux ME, Cho YJ, Koellhoffer EC, Pomeroy SL, Orkin SH, Roberts CWM. Epigenetic antagonism between Polycomb and SWI/SNF complexes during oncogenic transformation. Cancer Cell Oct 19;18(4):316-28, 2010. PMID: 20951942 PMCID: PMC2957473


2009

  • DelBove J, Kuwahara Y, Mora-Blanco EL, Godfrey V, Funkhouser WK, Fletcher CD, Van Dyke T, Roberts CW, Weissman BE. Inactivation of SNF5 cooperates with p53 loss to accelerate tumor formation in Snf5(+/-);p53(+/-) mice. Mol Carcinog Dec; 48(12):1139-48, 2009. PMID: 19676100  PMCID: PMC3527082

  • Wang X, Sansam CG, Thom CS, Metzger D, Evans JA, Nguyen PTL, Roberts CWM.Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent upon activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex.  Cancer Research69:8094-8101, 2009.PMID: 19789351 PMCID: PMC2763035

  • Bourgo RJ, Siddiqui H, Fox S, Solomon D, Sansam CG, Yaniv M, Muchardt C, Metzger D, Chambon P, Roberts CWM, Knudsen ES.  SWI/SNF-Deficiency Results in Aberrant Chromatin Organization, Mitotic Failure, and Diminished Proliferative Capacity. Molecular Biology of the Cell 20:3192-9, 2009. PMID: 19458193 PMCID: PMC2710832

  • Roberts CWM, Biegel JA. The role of SMARCB1/INI1 in development of rhabdoid tumor. Cancer Biology & Therapy 8:412-416, 2009. PMID: 19305156 PMCID: PMC2709499

  • McKenna ES, Roberts CWM. Epigenetics and cancer without genomic instability. Cell Cycle28:1-4, 2009. PMID: 19098432