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Nichols Lab: Selected Publications

2019


2018

  • Qian M, Cao X, Devidas M, Yang W, Cheng C, Dai Y, Carroll A, Heerema NA, Zhang H, Moriyama T, Gastier-Foster JM, Xu H, Raetz E, Larsen E, Winick N, Bowman WP, Martin PL, Mardis ER, Fulton R, Zambetti G, Borowitz M, Wood B, Nichols KE, Carroll WL, Pui CH, Mullighan CG, Evans WE, Hunger SP, Relling MV, Loh ML, Yang JJ. TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children. 2018; J Clin Oncol. PMCID: PMC5815403.

  • Wei X, Calvo-Vidal MN, Chen S, Wu G, Revuelta MV, Sun J, Zhang J, Walsh MF, Nichols KE, Joseph V, Snyder C, Vachon CM, McKay JD, Wang SP, Jayabalan DS, Jacobs LM, Becirovic D, Waller RG, Artomov M, Viale A, Patel J, Phillip JM, Chen-Kiang S, Curtin K, Salama M, Atanackovic D, Niesvizky R, Landgren O, Slager SL, Godley LA, Churpek J, Garber JE, Anderson KC, Daly MJ, Roeder RG, Dumontet C, Lynch HT, Mullighan CG, Camp NJ, Offit K, Klein RJ, Yu H, Cerchietti L, Lipkin SM. Germline mutations in lysine specific demethylase 1 (LSD1/KDM1A) confer susceptibility to multiple myeloma. Cancer Res. 2018. PMCID: PMC5955848.

  • Peled M, Tocheva AS, Sandigursky S, Nayak S, Philips EA, Nichols KE, Strazza M, Azoulay-Alfaguter I, Askenazi M, Neel BG, Pelzek AJ, Ueberheide B, Mor A. Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor. Proc Natl Acad Sci U S A. 2018. PMCID: PMC5776966.

  • Churchman ML, Qian M, Kronnie G, Zhang R, Yang W, Zhang H, Lana T, Tedrick P, Baskin R, Verbist K, Peters J, Devidas M, Raetz E, Larsen E, Martin PL, Bowman WP, Winick N, Mardis E, Fulton R, Stanulla M, Evans WE, Relling MV, Pui CH, Hunger SP, Loh ML, Handgretinger R, Nichols KE, Yang JJ, Mullighan CG. Germline IKZF1 variation and predisposition to acute lymphoblastic leukemia. Cancer Cell, 2018. PMCID: PMC5953820.

  • Wang Z, Wilson CL, Easton J, Thrasher A, Mulder H, Liu Q, Hedges DJ, Wang S, Rusch MC, Edmonson MN, Levy S, Lanctot JQ, Caron E, Shelton K, Currie K, Lear M, Patel A, Rosencrance C, Shao Y, Vadodaria B, Yergeau D, Sapkota Y, Brooke RJ, Moon W, Rampersaud E, Ma X, Chang TC, Rice SV, Pepper C, Zhou X, Chen X, Chen W, Jones A, Boone B, Ehrhardt MJ, Krasin MJ, Howell RM, Phillips NS, Lewis C, Srivastava D, Pui CH, Kesserwan CA, Wu G, Nichols KE, Downing JR, Hudson MM, Yasui Y, Robison LL, Zhang J. Genetic Risk for Subsequent Neoplasms Among Long-Term Survivors of Childhood Cancer. J Clin Oncol. 2018 Jul 10;36(20):2078-2087. doi: 10.1200/JCO.2018.77.8589. Epub 2018 May 30. PMID: 29847298

  • Wei X, Calvo-Vidal MN, Chen S, Wu G, Revuelta MV, Sun J, Zhang J, Walsh MF, Nichols KE, Joseph V, Snyder C, Vachon CM, McKay JD, Wang SP, Jayabalan DS, Jacobs LM, Becirovic D, Waller RG, Artomov M, Viale A, Patel J, Phillip J, Chen-Kiang S, Curtin K, Salama M, Atanackovic D, Niesvizky R, Landgren O, Slager SL, Godley LA, Churpek J, Garber JE, Anderson KC, Daly MJ, Roeder RG, Dumontet C, Lynch HT, Mullighan CG, Camp NJ, Offit K, Klein RJ, Yu H, Cerchietti L, Lipkin SM. Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma. Cancer Res. 2018 May 15;78(10):2747-2759. doi: 10.1158/0008-5472.CAN-17-1900. Epub 2018 Mar 20. PMID:29559475


2017

  • Schwartz JR, Wang S, Ma J, Lamprecht T, Walsh M, Song G, Raimondi SC, Wu G, Walsh MF, McGee RB, Kesserwan CA, Nichols KE, Cauff BE, Ribiero RC, Wlodarski M, Klco JM. Germline SAMD9 mutation in siblings with Monosomy 7 and Myelodysplastic Syndrome. Leukemia. 2017;31(8):1827-1830. PMCID: PMC5540771.

  • Minoia F, Bovis F, Davì S, Insalaco A, Lehmberg K, Shenoi S, Weitzman S, Espada G, Gao YJ, Anton J, Kitoh T, Kasapcopur O, Sanner H, Merino R, Astigarraga I, Alessio M, Jeng M, Chasnyk V, Nichols KE, Huasong Z20 Li C, Micalizzi C, Ruperto N, Martini A, Cron RQ, Ravelli A, Horne A; Pediatric Rheumatology International Trials Organization; Childhood Arthritis and Rheumatology Research Alliance; Pediatric Rheumatology Collaborative Study Group; Histiocyte Society. Development and initial validation of the MH score, a diagnostic tool that differentiates primary hemophagocytic lymphohistiocytosis from macrophage activation syndrome. J Pediatr. 2017;189:72-78.e3. PMID: 28807357.

  • Schwartz JR, Ma J, Lamprecht T, Walsh M, Wang S, Bryant V, Song G, Wu G, Easton J, Kesserwan CA, Nichols KE, Mullighan CG, Ribeiro RC, Klco JM. The genomic landscape of Pediatric Myelodysplastic Syndrome. Nat Commun. 2017; 8(1):1557. PMCID: PMC5691144.

  • Lemberg K, Ochi F, Nichols KE, Ishii E. Hemophagocytic lymphohistiocytosis associated with malignancies and Epstein-Barr virus infection. In Histiocytic neoplasms and related disorders. Abla O, Janka G, eds, Springer Publishing, 2017.

  • Messick TG, Nichols KE. Infectious Mononucleosis and Other Epstein-Barr Virus–Related Disorders. Messick TG, Nichols KE. In Wintrobe’s Clinical Hematology, 14th edition, Greer JP, Appelbaum F, Arber DA, Dispenzieri A, Fehniger T, Glader B, List AF, Means RT, Jr., Rodgers GM, eds, 2017.

  • Verbist K, Nichols KE. Cytokine Storm Syndromes Associated with Epstein Barr Virus. In Histiocytic Neoplasms and Related Disorders, Abla O, Janka G, eds, Springer Publishing, 2017.

  • Quinn E, Nichols KE. Cancer predisposition syndromes associated with myeloid malignancy. Semin Hematol Apr;54(2):115-122, 2017. doi: 10.1053/j.seminhematol.2017.04.003. Epub 2017 Apr 7. Review. PMID: 28637615


2016

  • Hyung-Joon Kwon H-J, Choi G-E, Ryu S, Kwon SJ, Kim SC, Booth C, Nichols KE, Kim HS. Stepwise phosphorylation of p65 promotes NF-κB activation and NK cell responses during target cell recognition. Nature Communications 7:11686, 2016. doi:10.1038/ncomms11686

  • Guan P, Bassiri H, Patel NP, Nichols KE, Das R. Invariant natural killer T cells in hematopoietic stem cell transplantation: killer choice for natural suppression. Bone Marrow Transplantation 2016 Feb 15. doi: 10.1038/bmt.2015.335. [Epub ahead of print] Review. PMID: 26878658

  • Das R, Guan P, Sprague L, Verbist K, Tedrick P, Qi A, Cheng C, Kurachi M, Levine RL, Wherry J, Canna S, Behrens EM, Nichols K. Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis. Blood 2015 (in press).

  • Ruffo E, Malacarne V, Larsen SE, Das R, Patrussi L, Wülfing C, Biskup C, Kapnick SM, Verbist K, Tedrick P, Schwartzberg PL, Baldari CT, Rubio I, Nichols KE, Snow AL, Baldanzi G, Graziani A. Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1. Sci Transl Med Jan 13;8(321):321ra7, 2016. doi: 10.1126/scitranslmed.aad1565


2015

  • Topka S, Vijai J, Walsh MF, Jacobs L, Maria A, Villano D, Gaddam P, Wu G, McGee RB, Quinn E, Inaba H, Hartford C, Pui CH, Pappo A, Edmonson M, Zhang MY, Stepensky P, Steinherz P, Schrader K, Lincoln A, Bussel J, Lipkin SM, Goldgur Y, Harit M, Stadler ZK, Mullighan C, Weintraub M, Shimamura A, Zhang J, Downing JR, Nichols KE, Offit K. Germline ETV6 Mutations Confer Susceptibility to Acute Lymphoblastic Leukemia and ThrombocytopeniaPLoS Genet. 11(6):e1005262, 2015. doi:10.1371/journal.pgen.1005262. PMID: 26102509.

  • Moriyama T, Metzger ML, Wu G, Nishii R, Qian M, Devidas M, Yang W, Cheng C, Cao X, Quinn E, Raimondi S, Gastier-Foster JM, Raetz E, Larsen E, Martin PL, Bowman WP, Winick N, Komada Y, Wang S, Edmonson M, Xu H, Mardis E, Fulton R, Pui CH, Mullighan C, Evans WE, Zhang J, Hunger SP, Relling MV, Nichols KE, Loh ML, Yang JJ. Germline genetic variation in ETV6 and risk of childhood acute lymphoblastic leukaemia: a systematic genetic studyLancet Oncol. 16(16):1659-66, 2015. doi: 10.1016/S1470-2045(15)00369-1. PMID: 26522332.

  • Invariant natural killer T cells in hematopoietic stem cell transplantation: killer choice for natural suppression Guan P, Bassiri H, Patel NP, Nichols KE, Das R. Bone Marrow Transplantation, 2015, in press.

  • Spessott WA, Sanmillan ML, McCormick M, Patel N, Villanueva J, Zhang K, Nichols KE*, Giraudo CG. Hemophagocytic lymphohistiocytosis caused by dominant negative mutations in STXBP2 that inhibit SNARE-mediated membrane fusion. Blood, 2015 (in press).*Co-corresponding author.


2014

  • Menard L, Chamberlain N, Cantaert T, Tangye SG, Riminton S, Church JA, Klion A, Cunninham-Rundles C, Nichols KE, Meffre E. Signaling Lymphocytic Activation Molecule (SLAM)-associated protein (SAP) regulates human B cell tolerance. J Allergy Clin Immunol 133(4):1149-1161, 2014. PMCID: PMC4077428.

  • Bassiri H, Das R, Guan P, Barrett DM, Brennan PJ, Banerjee PP, Wiener SJ, Orange JS, Brenner MB, Grupp SA, Nichols KE. iNKT cell cytotoxic responses control T-lymphoma growth in vitro and in vivo. Cancer Immunol Res 2(1):59-69, 2014. PMCID: PMC3927984.


2013

  • Bassiri H, Das R, Nichols KE. Invariant NKT cells: Killers and conspirators against cancer. Oncoimmunology Dec 1;2(12):e27440, 2013. Epub 2014 Jan 3. PMID: 24575380

  • Chaigne-Delalande B, Li F-Y, O’Connor GM, Lukacs MJ, Jiang P, Zheng L, Biancalana M, Pittaluga S, Matthews HF, Jancel T, Hetherington M, Bleesing JJ, Marsh A, Kuijpers TW, Nichols KE, Lucas CL, Nagpal S, Mehmet H, Su HC, Cohen JI, Uzel G, Lenardo MJ. Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection. Science 341(6142):186-191, 2013. PMCID: PMC3894782.

  • Teachey DT, Rheingold SR, Maude SL, Barrett DM, Seif AE, Nichols KE, Suppa EK, Kalos M, Berg RA, Fitzgerald JC, Aplenc R, Gore L, Grupp SA. Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine directed therapy. Blood 121(26):5154-5157, 2013. PMCID: PMC4123427.

  • Chellapandian D, Das R, Zelley K, Wiener S, Zhao H, Teachey DT, Nichols KE. Treatment of Epstein-Barr virus-induced hemophagocytic lymphohistiocytosis with rituximab-containing immune-chemotherapeutic regimens. Br J Hematol 162(3):376-382, 2013. PMCID: PMC3776423.

  • May RM, Okumura M, Hsu C-J, Bassiri H, Yang E, Rak G, Mace EM, Philip NH, Zhang W, Baumgart T, Orange JS, Nichols KE, Kambayashi T. Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function. Blood 121(16):3135-3146, 2013. PMCID: PMC3630829.

  • Das R, Bassiri H, Guan P, Wiener S, Banerjee P, Zhong M-C, Veillette A, Orange JS, Nichols KE. The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation. Blood 121(17):3386-3395, 2013. PMCID: PMC3637014.


2012

  • Palendira U, Low C, Bell AI, Ma CS, Abbott RJM, Phan TG, D Riminton S, Choo S, Smart JM, Lougaris V, Giliani S, Buckley RH, Grimbacher B, Alvaro F, Klion AD, Nichols KE, Adelstein S, Rickinson AB, Tangye SG. Expansion of somatically reverted memory CD8+ T cells in X-linked lymphoproliferative disease is due to selective pressure from Epstein Barr virus. J Exp Med 209(5):913-924, 2012. PMCID: PMC3348103.


2011

  • Baldanzi G, Pighini A, Bettio V, Rainero E, Traini S, Chianale F, Porporato P, Filigheddu N, Mesturini R, Song S, Schweighoffer T, Patrussi L, Baldari CT, Zhong XP, van Blitterswijk WJ, Sinigaglia F, Nichols KE, Rubio I, Parolini O, Graziani A. SAP-mediated inhibition of diacylglycerol kinase alpha regulates TCR-induced diacylglycerol signalling. J Immunol 187(11):5941-5951, 2011. PMCID: PMC3221890.

  • Rothman JA, Das R, Teachey DT, Paessler ME, Nichols KE. Rapamycin does not control hemophagocytic lymphohistiocytosis in LCMV-infected perforin-deficient mice. Pediatr Blood Cancer 57(7):1239-1243, 2011. PMID: 21681935.

  • Jyonouchi S, Abraham V, Orange JS, Spergel JM, Gober L, Dudek E, Saltzman R, Nichols KE*, Cianferoni A. Invariant natural killer T cells from food allergic versus non-allergic children exhibit differential responsiveness to milk derived sphingomyelin. J Allergy Clin Immunol 128(1):102-109, 2011. PMCID: PMC3129401 *Co-corresponding author.


2010

  • Kovalovsky D, Alonzo ES, Uhe OU, Eidson M, Nichols KE, Sant’Angelo DB. PLZF induces the spontaneious acquisition of memory/effector functions in T cells independently of Natural Killer T cell related signals. J Immunol 184(12):6746-6755, 2010. PMID: 20495068.

  • Alonzo E, Gottschalk R, Das J, Egawa T, Hobbs R, Pandolfi P, Pereira P, Nichols KE, Koretzky G, Jordan M, Sant'Angelo D. Development of Promyelocytic Zinc Finger and ThPOK-Expressing Innate {gamma}{delta} Innate T cells is controlled by strength of TCR signaling and Id3. J Immunol 184(3):1268-1279, 2010. PMCID: PMC3991695.


2009

  • Lenox LE, Kambayashi T, Okamura M, Prieto C, Sauer K, Bunte R, Jordan MS, Koretzky GA, Nichols KE. Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis. J Allergy Clin Immunol 124(5):1088-1098, 2009. PMCID: PMC2778804.

  • Snow AL, Marsh R, Krummey SM, Roehrs P, Young LR, Kejian Zhang, Jack van Hoff, Dhar D, Nichols KE, Filipovich AH, Su HC, Bleesing JJ, Lenardo MJ. Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency. J Clin Invest 119(10):2976-2989, 2009. PMCID: PMC2752081.

  • Cen O, Guzman L, Jain J, Bassiri H, Nichols KE, Stain PL. The adaptor molecule SAP regulates IFNg and IL-4 production in Va14 transgenic NK cells via effects on GATA-3 and T-bet expression. J Immunol 182(3):1370-1378, 2009. PMCID: PMC2630172.


2008

  • Nunez-Cruz S, Yeo WCJ, Rothman J, Ojha P, Bassiri H, Juntilla M, Davidson D, Veillette A, Koretzky GA, Nichols KE. Differential requirement for the SAP-Fyn interaction during NKT cell development and activation. J Immunol 181(4):2311-2320, 2008. PMC2585984.

  • Baev DV, Caielli C, Coccia M, Ronchi F, Cacciotti F, Nichols KE, Falcone M. Impaired SLAM-SLAM homotypic interaction between invariant NKT cells and dendritic cells affects differentiation of IL-4/IL-10 secreting NKT2 cells in NOD mice. J Immunol 181(2):869-877, 2008. PMCID: PMC2587206.

  • Jordan M, Smith J, Burns J, Austin JE, Nichols KE, Aschenbrenner A, Koretzky GA. Complementation in trans of altered thymocyte development in knock-in mice expressing mutant forms of SLP-76. Immunity 28(3):359-369, 2008. PMCID: PMC2323515.


2007

  • Clemens RA, Lenox LE, Kambayashi T, Bezman N, Maltzman JS, Nichols KE, Koretzky GA. Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil mediated tissue damage while maintaining effective bacterial killing. J Immunol 178(7):4606-4614, 2007.


2006

  • Ma CS, Pittalugia S, Avery DT, Hare NJ, Maric I, Klion AD, Nichols KE, Tangye SG. Selective generation of functionally somatically mutated IgM+CD27+, but not isotype-switched, memory B cells in X-linked lymphoproliferative disease. J Clin Invest 116(2):322-333, 2006.


2005

  • Ma CS, Hare NJ, Nichols KE, Dupre L, Andolfi G, Roncarolo MG, Adelstein S, Hodgkin PD, Tangye SG. Impaired humoral immunity in XLP is associated with defective IL-10 production by CD4+ T cells. J Clin Invest 115(4):1049-1059, 2005.

  • Nichols KE, Hom J, Gong S-Y, Ganguly A, Ma C, Cannons J, Tangye SG, Schwartzberg PL, Koretzky GA, Stein PL. Regulation of NKT cell development by SAP, the protein defective in X-linked lymphoproliferative disease. Nat Med 11(3):340-345, 2005.

  • Milone M, Tsai DE, Hodinka R, Silverman LB, Stadtmauer EA, Malbran A, Wasik M, Nichols KE. Use of B-cell directed therapy to treat primary Epstein-Barr virus (EBV) infection in patients with X-linked lymphoproliferative disease (XLP). Blood 105(3):994-996, 2005.


2004

  • Cannons JL, Hill B, Yu LJ, Mijares L, Nichols KE, Antonellis A, Koretzky G, Gardner K, Schwartzberg PL. SAP modulates TH2 differentiation and PKC-theta-mediated activation of the NFkB pathway. Immunity 21(5):693-706, 2004.

  • Chemnitz JM, Parry RV, Nichols KE, June CH, Riley JL. SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation. J Immunol 173(2):445-454, 2004.

  • Malbran A, Belmonte L, Ruibal-Ares B, Bare P, Nichols KE, de Braco MME. Defects in CD27+ memory B cells and CCR4+ T cells occurring in association with elevated serum Epstein-Barr virus (EBV) loads in XLP patients surviving primary EBV infection. Blood 103(5):1625-1631, 2004.

  • Nichols KE, Haines K, Myung PS, Dmowski S, Meyers E, Jumaa H, Shedlock DJ, Shen H, Koretzky GA. Macrophage activation and Fcg-receptor mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors. J Leukoc Biol 75(3):541-552, 2004.


2003

  • Tangye SG, Nichols KE, Hare NJ, van de Weerdt BCM. Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation. J Immunol 171(5):2485-2495, 2003.

  • Zhong XP, Hainey EA, Olenchock BA, Jordan MS, Maltzman JS, Nichols KE, Shen H, Koretzky GA. Enhanced T cell responses due to diacylglycerol kinase zeta deficiency. Nat Immunol 4(9):882-890, 2003.


2001

  • Arico M, Imashuku S, Clementi, R, Hibi S, Teramura T, Danesino C, MD, Haber DA, Nichols KE. Hemophagocytic lymphohistiocytosis due to germline mutations in SH2D1A, the X-linked lymphoproliferative disease gene. Blood 97:1131-1133, 2001.


2000

  • Tangye SG, Lanier LL, Phillips JH, Nichols KE. Functional requirement for SH2D1A in 2B4-mediated activation of human Natural Killer Cells. J Immunol 165:2932-2936, 2000.

  • Nichols KE, Crispino J, Poncz M, White J, Orkin S, Maris J, Weiss MJ. Familial dyserythropoietic anemia and thrombocytopenia due to an inherited mutation in the transcription factor GATA-1 gene. Nat Genet 24(3):266-270, 2000.


1998

  • Nichols KE, Harkin DP, Levitz S, Krainer M, Kolquist A, Gresko C, Bernard A, Ferguson M, Zuo L, Snyder E, Buckler AJ, Wise C, Ashley J, Lovett M, Valentice M, Look AT, Housman DE, Haber DA. Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc Natl Acad Sci USA 95:13765-13770, 1998.


1996

  • Lamartine J, Nichols KE (co-first author), Luo Y, Krainer M, Heitzmann F, Bernard A, Gaudi S, Lenoir GM, Sullivan JL, Ikeda JE, Porta G, Romeo G, Haber DA, Sylla BS, Harkin DP. Physical map and cosmid contig encompassing a new interstitial deletion of the X-linked lymphoproliferative syndrome region. Eur J Hum Genet 4:342-351, 1996.