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Klco Lab: About Us

Welcome to the lab of Jeffery Klco MD, PhD

The mission of the Klco lab is to define the molecular and biological causes of myeloid tumors in children, including myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). To accomplish this goal, we use a series of genomic approaches (whole genome, whole exome, RNA-seq, single cell genomics) to identify the spectrum of somatic and germline mutations that define these different pediatric malignancies. We then utilize a range of in vitro and in vivo approaches to functionally interrogate these genes and pathways. This includes establishing different genetically engineered mouse models, primary cell cultures (e.g. cord blood CD34 cells), and patient-derived xenograft approaches coupled with CRISPR-Cas9 for genome engineering and lentiviral expression models.

We have established close collaborations with different research and clinical investigators at St Jude, in large part through the St. Jude Comprehensive Cancer Center Hematological Malignancies Program, with the ultimate goal of using our studies to transform the diagnosis and/or management of children with myeloid neoplasms. We are part of a multi-PI, multi-institutional FusOnc grant, led by Charles Mullighan, on NUP98 fusion acute leukemias. We have also established collaborations with numerous investigators in Computational Biology at St Jude, notably Xiaotu Ma and Jinghui Zhang. These collaborations also extend beyond St Jude to include Kevin Shannon (UCSF) on pediatric MDS and monosomy 7 and Soheil Meshinchi (Fred Hutch, COG) for pediatric AML.

Our research is supported by multiple sources, including NHLBI and NCI. In addition, we receive funding from the EvansMDS Foundation and the Burroughs Welcome Fund, and previously through the V Foundation for Cancer Research.

Keywords

MDS, AML, hematopoiesis, genomics, patient-derived xenografts

Career Opportunities

The laboratory provides a rich environment for advanced training in experimental hematology, including both mouse and human models. Previously trainees have successfully competed for NIH awards (K08, F32), as well as awards through private foundations, and obtained academic faculty jobs. We also have extensive support and collaborations in computational biology to acquire the needed skills to navigate genomic data. Potential postdoctoral fellows with experience and/or interest in joining the laboratory are strongly encouraged to contact Dr. Klco. Please e-mail your cover letter and CV to: jeffery.klco@stjude.org.

Short-term Internship Opportunities

Motivated undergraduates or medical students with some previous lab experience are welcomed to discuss opportunities with Dr. Klco. Please e-mail your cover letter and CV to: jeffery.klco@stjude.org.

News Releases and Feature Stories

Overcoming the Odds of Familial Monosomy 7

Solution to medical mystery may help some children avoid bone marrow transplantation

Researchers reveal genomic landscape of core-binding factor acute myeloid leukemia