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Supplementary Information

Identification of genes associated with chemotherapy cross-resistance and treatment response in childhood acute lymphoblastic leukemia.

Supplemental Table 7: Overlap of genes discriminating multiple-drug resistance and genes discriminating ALL subtypes

A. The overlap with the top 100 gene probe sets discriminating ALL genetic subtypes (TEL-AML1 [TEL], hyperdiploid [HD], T-lineage [T]) (Ross et al., 2003; Yeoh et al., 2002) and the 200 gene probe sets discriminating VCR-ASP discordant resistance. Only 13 probe sets (11 genes) were in common.

B. Furthermore, among the top 100 gene probe sets discriminating ALL genetic subtypes (Ross et al., 2003; Yeoh et al., 2002) and the 51 gene probe sets discriminating cross- resistance, there were only three genes in common.

A
Probe ID ALL Subtype Title Gene Symbol
200709_at TEL1 FK506 binding protein 1A, 12kDa FKBP1A
202838_at TEL1 fucosidase, alpha-L- 1, tissue FUCA1
203611_at TEL1 telomeric repeat binding factor 2 TERF2
203710_at TEL1 inositol 1,4,5-triphosphate receptor, type 1 ITPR1
204849_at TEL1 transcription factor-like 5 (basic helix-loop-helix) TCFL5
205267_at TEL1 POU domain, class 2, associating factor 1 POU2AF1
209695_at TEL1 protein tyrosine phosphatase type IVA, member 3 PTP4A3
221494_x_at HD1 muscle specific gene M9
203680_at HD2 protein kinase, cAMP-dependent, regulatory, type II, beta PRKAR2B
204849_at TEL2 transcription factor-like 5 (basic helix-loop-helix) TCFL5
221748_s_at TEL2 Homo sapiens cDNA FLJ32766 fis, clone TESTI2001862
200709_at TEL2 FK506 binding protein 1A, 12kDa FKBP1A
221747_at TEL2 Homo sapiens cDNA FLJ32766 fis, clone TESTI2001862
B
Probe ID ALL Subtype Title Gene Symbol
200709_at HD1 transcription factor 4 TCF4
202838_at T2 CD79B antigen (immunoglobulin-associated beta) CD79B
203611_at T2 immunoglobulin heavy constant mu IGHM

1 Ross et al., 2003; 2 Yeoh et al., 2002

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