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Supplementary Information

Identification of genes associated with chemotherapy cross-resistance and treatment response in childhood acute lymphoblastic leukemia.

Supplemental Figure 4: Principal component analysis plot of genes discriminating cross-resistance and VCR-ASP discordant resistance.

Illustrated are the first three components of the principal component analysis (PCA) to visualize differences among ALL cells using the gene expression signatures identified. A. Expression of 51 gene probe sets that significantly discriminate cross-resistant (red; n=29) from cross-sensitive (green; n=38) B-lineage ALL patients (P<0.0001) in three-dimensional space. B. Gene expression of 200 gene probe sets (P<0.00006) that significantly discriminate VCR-resistant (VCR-R) plus ASP-sensitive (ASP-S) (orange; n=34) patients from VCR-sensitive plus ASP-resistance patients (blue; n=42) were used.

Figure 4

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