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Supplementary Information

Gene-expression patterns in drug resistant acute lymphoblastic leukemia cells and response to treatment.

Supplemental Table 8: Multivariate analysis of gene expression and known prognostic factors (age, WBC count) to discriminate in vitro drug resistance.

Multiple logistic regression was used with gene expression score (described in Supplemental Table 6), age and WBC count as continuous variables for the analysis in B-lineage ALL. An odds ratio >1 indicates increased probability of in vitro resistance.

 

predictor

odds ratio (95% C.I.)

P-value

PRED

gene expression score

57.8 (4.9-681.6)

0.001

 

age [years]

1.17 (1.01-1.36)

0.038

 

WBC count [109/L]

1.0 (0.98-1.01)

0.427

VCR

gene expression score

13.5 (1.97-92.6)

0.008

 

age [years]

1.0 (0.89-1.13)

0.995

 

WBC count [109/L]

0.99 (0.99-1.0)

0.084

ASP

gene expression score

22.1 (4.8-102.6)

<0.001

 

age [years]

1.13 (1.01-1.26)

0.033

 

WBC count [109/L]

1.0 (0.99-1.01)

0.792

DNR

gene expression score

151.2 (4.1-5533.6)

0.006

 

age [years]

1.04 (0.93-1.17)

0.455

 

WBC count [109/L]

1.0 (0.99-1.0)

0.273

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