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Supplementary Information

Gene-expression patterns in drug resistant acute lymphoblastic leukemia cells and response to treatment.

Supplemental Table 5 : Prediction accuracy using gene expression profiles for classification of drug resistant and sensitive acute lymphoblastic leukemia.

Prediction accuracy in randomly selected cohorts comprising 1/3 of the training set for each antileukemic agent using 30, 50 or 100 reselected top probe sets. The median prediction accuracy is shown with corresponding P-values and the 95 percent confidence interval (C.I.) for prednisolone (PRED), vincristine (VCR), asparaginase (ASP) and daunorubicin (DNR) (a) based on all patients and (b) for only patients with B-lineage acute lymphoblastic leukemia. The prediction accuracies were even higher (c, d), when genes were selected only once from the entire training set, and then used to predict sensitive or resistant phenotypes in randomly selected cohorts comprising 1/3 of the population.

a. All patients
  N accuracy
[%]
95%
C.I.
P-value
PRED 30 71 58-81 0.031
  50 71 58-81 0.031
  100 71 58-81 0.031
VCR 30 68 59-78 0.029
  50 71 59-79 0.012
  100 71 59-79 0.012
ASP 30 67 52-76 0.045
  50 67 52-79 0.045
  100 67 55-78 0.045
DNR 30 73 60-80 0.007
  50 73 60-80 0.007
  100 73 58-76 0.007
b. B-lineage
accuracy
[%]
95%
C.I.
P-value
75 63-88 0.025
75 63-88 0.025
75 67-87 0.025
74 62-85 0.010
76 65-85 0.004
76 65-85 0.004
71 60-83 0.018
71 57-83 0.018
71 60-80 0.018
76 65-85 0.004
76 65-85 0.004
76 67-84 0.004
c. All patients
  N accuracy
[%]
95%
C.I.
PRED 30 95 88-100
  50 93 86-100
VCR 30 81 71-88
  50 81 74-90
ASP 30 81 71-90
  50 83 71-91
DNR 30 90 83-95
  50 90 86-98
d. B-lineage
accuracy
[%]
95%
C.I.
98 90-100
98 90-100
81 71-88
81 71-91
83 71-90
86 74-93
95 90-100
95 90-100

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