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Supplementary Information

Gene-expression patterns in drug resistant acute lymphoblastic leukemia cells and response to treatment.

Supplemental Figure 13 : Gene Ontology classification of genes discriminating drug resistance in patients with acute lymphoblastic leukemia (B- and T-lineage ALL).

Figure 13

Functional classification in Gene Ontology (GO) of the probe sets discriminating drug resistance in ALL compared to the entire genome, as represented by all probe sets on the U133A GeneChip (22,283 probe sets; 12,983 with GO annotation) for four antileukemic agents. For prednisolone (PRED) 32 significant probe sets were identified, for vincristine (VCR) there were 54 significant probe sets, for asparaginase (ASP) 52 probe sets, and for daunorubicin (DNR) 15 probe sets discriminated resistant and sensitive ALL cells. There were 19, 33, 30 and 11 probe sets annotated in the GO database for PRED, VCR, ASP, and DNR, respectively. Functional categories that were proportionally over-represented in discriminating resistance drug compared to the entire genome, are indicated by an asterisk (P< 0.05, Fisher's exact test). Redundant gene symbols were counted as one.

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