Laboratories:
- By PI Laboratory:
-
- Bashford, Don, PhD
- Chen, Taosheng, PhD, PMP®
- Evans, William E., PharmD
- Fujii, Naoaki, PhD
- Guy, Kip R., PhD
- Kriwacki, Richard W., PhD
- McKinney-Freeman, Shannon, PhD
- Mittag, Tanja, PhD
- Mullighan, Charles, MBBS(Hons), MSc, MD
- Pillai, Asha B., MD
- Potter, Philip M., PhD
- Rivas, Fatima, PhD
- Snyder, Scott E., PhD
- Webb, Thomas R., PhD
- Zhang, Jinghui, PhD
Supplemental Data:
- By Author
-
- Rabin, K. R.
- Radin, Jana N.
- Radtke, Ina
- Rai, Shesh N.
- Raimondi, Susana, PhD
- Rakestraw, Karen M.
- Reaman, G.
- Relling, Mary V., PharmD
- Ribeiro, Raul, MD
- Rivas, Fatima, PhD
- Rochette, Sheila A., PhD
- Rodriguez-Galindo, Carlos, MD
- Ross, Mary E., MD, PhD
- Roussel, Martine F., PhD
- Ruan, Hong
- Rubnitz, Jeffrey, MD, PhD
- Rutka, Jim
Select last name: ABCD EFGHIJKLMNO PQRSTUVWXY Z See Full List
Shelat Lab: About Us
Back row (L to R): Gregory Miller, Anang Shelat, David Perkins.
Front row (L to R): Peter Shu, Hong Ruan, Pam Warrington, Enas Ahmed,
Kavitha Bharatham, Heather Ross, Cynthia Jeffries.
Shelat Research Group
Advances in automation and miniaturization technologies in the last decade have enabled unprecedented interrogation of biology at multiple scales – the “omics” revolution. For example, structural genomics offers atomic resolution of the interactions between biological macromolecules and ligands; the cellular inventory of RNA transcripts can be explored via microarrays; and high-throughput sequencing can detect genetic variation in populations. A key challenge for the life sciences will be to resolve how best to integrate these disparate streams of information. The Shelat research group employs techniques from computational chemistry and informatics to learn from the wealth of available biological and chemical data, and then, uses the insights gained to guide the development of novel therapeutics.
Lead Discovery Informatics (LDI) Group
The LDI group is tasked with building and maintaining a chemo-centric infrastructure for the Chemical Biology and Therapeutics Department. We work with every CBT group and their external collaborators to ensure that all relevant biological and chemical data is captured, indexed, and made readily available.
Our mission includes the following:
- Building robust workflows and data pipelines for lab automation
- Deploying, customizing, and maintaining laboratory information management systems (LIMS)
- Developing new tools for visualizing and analyzing molecular properties and relationships
Specific information about the existing informatics infrastructure is available on our wiki site and on SharePoint (for SJ internal use only).
Compound Management (CM) Group
CM serves the critical role of making chemical matter readily available for biological screening. We provide the following services:
- Compound purchase, acquisition, and shipment
- Registration and reformatting from powders and external plates, and the creation of dose-response plates and other special format plates;
- Delivery and return of screening plates and cherry-pick orders for high-throughput screens
- Processing of compounds synthesized via high-throughput chemistry
Specific information about CM is available on SharePoint (for SJ internal use only). View more information about the St. Jude Chemical library (for SJ internal use only).