Xu H, Cheng C, Devidas M, Pei D, Fan Y, Yang W, Neale G, Scheet P, Burchard EG, Torgerson DG, Eng C, Dean M, Antillon F, Winick NJ, Martin PL, Willman CL, Camitta BM, Reaman GH, Carroll WL, Loh M, Evans WE, Pui CH, Hunger SP, Relling MV, Yang JJ. ARID5B Genetic Polymorphisms Contribute to Racial Disparities in the Incidence and Treatment Outcome of Childhood Acute Lymphoblastic Leukemia. J Clin Oncol. 2012 Mar 1;30(7):751-7. Epub 2012 Jan 30. PubMed PMID: 22291082.
Bhojwani D, Pei D, Sandlund JT, Jeha S, Ribeiro RC, Rubnitz JE, Raimondi SC, Shurtleff S, Onciu M, Cheng C, Coustan-Smith E, Bowman WP, Howard SC, Metzger ML, Inaba H, Leung W, Evans WE, Campana D, Relling MV, Pui CH. ETV6-RUNX1-positive childhood acute lymphoblastic leukemia: improved outcome with contemporary therapy. Leukemia. 2012 Feb;26(2):265-70. doi: 10.1038/leu.2011.227. Epub 2011 Aug 26. PubMed PMID: 21869842.
Kawedia JD, Liu C, Pei D, Cheng C, Fernandez CA, Howard SC, Campana D, Panetta JC, Bowman WP, Evans WE, Pui CH, Relling MV. Dexamethasone exposure and asparaginase antibodies affect relapse risk in acute lymphoblastic leukemia. Blood. 2012 Feb 16;119(7):1658-64. Epub 2011 Nov 23. PubMed PMID: 22117041.
Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen X, Wang J, Rusch M, Lu C, Chen SC, Wei L, Collins-Underwood JR, Ma J, Roberts KG, Pounds SB, Ulyanov A, Becksfort J, Gupta P, Huether R, Kriwacki RW, Parker M, McGoldrick DJ, Zhao D, Alford D, Espy S, Bobba KC, Song G, Pei D, Cheng C, Roberts S, Barbato MI, Campana D, Coustan-Smith E, Shurtleff SA, Raimondi SC, Kleppe M, Cools J, Shimano KA, Hermiston ML, Doulatov S, Eppert K, Laurenti E, Notta F, Dick JE, Basso G, Hunger SP, Loh ML, Devidas M, Wood B, Winter S, Dunsmore KP, Fulton RS, Fulton LL, Hong X, Harris CC, Dooling DJ, Ochoa K, Johnson KJ, Obenauer JC, Evans WE, Pui CH, Naeve CW, Ley TJ, Mardis ER, Wilson RK, Downing JR, Mullighan CG. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature. 2012 Jan 11;481(7380):157-63. doi:10.1038/nature10725. PubMed PMID: 22237106; PubMed Central PMCID: PMC3267575.
Ramsey LB, Bruun GH, Yang W, Treviño LR, Vattathil S, Scheet P, Cheng C, Rosner GL, Giacomini KM, Fan Y, Sparreboom A, Mikkelsen TS, Corydon TJ, Pui CH, Evans WE, Relling MV. Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition. Genome Res. 2012 Jan;22(1):1-8. Epub 2011 Dec 6. PubMed PMID: 22147369; PubMed Central PMCID: PMC3246196.
Diouf B, Cheng Q, Krynetskaia NF, Yang W, Cheok M, Pei D, Fan Y, Cheng C, Krynetskiy EY, Geng H, Chen S, Thierfelder WE, Mullighan CG, Downing JR, Hsieh P, Pui CH, Relling MV, Evans WE. Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells. Nat Med. 2011 Sep 25;17(10):1298-303. doi: 10.1038/nm.2430. PubMed PMID: 21946537; PubMed Central PMCID: PMC3192247.
Paugh SW, Stocco G, McCorkle JR, Diouf B, Crews KR, Evans WE. Cancer pharmacogenomics. Clin Pharmacol Ther. 2011 Sep;90(3):461-6. doi:10.1038/clpt.2011.126. Epub 2011 Jul 27. Review. Erratum in: Clin Pharmacol Ther. 2011 Dec;90(6):893. PubMed PMID: 21796115.
Mikkelsen TS, Sparreboom A, Cheng C, Zhou Y, Boyett JM, Raimondi SC, Panetta JC, Bowman WP, Sandlund JT, Pui CH, Relling MV, Evans WE. Shortening infusion time for high-dose methotrexate alters antileukemic effects: a randomized prospective clinical trial. J Clin Oncol. 2011 May 1;29(13):1771-8. Epub 2011 Mar 28. PubMed PMID: 21444869; PubMed Central PMCID: PMC3107765.
Yang JJ, Cheng C, Devidas M, Cao X, Fan Y, Campana D, Yang W, Neale G, Cox NJ, Scheet P, Borowitz MJ, Winick NJ, Martin PL, Willman CL, Bowman WP, Camitta BM, Carroll A, Reaman GH, Carroll WL, Loh M, Hunger SP, Pui CH, Evans WE, Relling MV. Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia. Nat Genet. 2011 Mar;43(3):237-41. Epub 2011 Feb 6. PubMed PMID: 21297632; PubMed Central PMCID: PMC3104508.
Relling MV, Gardner EE, Sandborn WJ, Schmiegelow K, Pui CH, Yee SW, Stein CM, Carrillo M, Evans WE, Klein TE; Clinical Pharmacogenetics Implementation Consortium. Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing. Clin Pharmacol Ther. 2011 Mar;89(3):387-91. Epub 2011 Jan 26. Erratum in: Clin Pharmacol Ther. 2011 Dec;90(6):894. PubMed PMID: 21270794; PubMed Central PMCID: PMC3098761.
Pui CH, Pei D, Campana D, Bowman WP, Sandlund JT, Kaste SC, Ribeiro RC, Rubnitz JE, Coustan-Smith E, Jeha S, Cheng C, Metzger ML, Bhojwani D, Inaba H, Raimondi SC, Onciu M, Howard SC, Leung W, Downing JR, Evans WE, Relling MV. Improved prognosis for older adolescents with acute lymphoblastic leukemia. J Clin Oncol. 2011 Feb 1;29(4):386-91. Epub 2010 Dec 20. PubMed PMID: 21172890; PubMed Central PMCID: PMC3058285.
Chen SH, Yang W, Fan Y, Stocco G, Crews KR, Yang JJ, Paugh SW, Pui CH, Evans WE, Relling MV. A genome-wide approach identifies that the aspartate metabolism pathway contributes to asparaginase sensitivity. Leukemia. 2011 Jan;25(1):66-74. Epub 2010 Nov 12. PubMed PMID: 21072045; PubMed Central PMCID: PMC3097057.
Pounds S, Cao X, Cheng C, Yang JJ, Campana D, Pui CH, Evans WE, Relling MV. Integrated analysis of pharmacologic, clinical and SNP microarray data using Projection Onto the Most Interesting Statistical Evidence with Adaptive Permutation Testing. Int J Data Min Bioinform. 2011;5(2):143-57. PubMed PMID: 21516175; PubMed Central PMCID: PMC3080017.
Panetta JC, Sparreboom A, Pui CH, Relling MV, Evans WE. Modeling mechanisms of in vivo variability in methotrexate accumulation and folate pathway inhibition in acute lymphoblastic leukemia cells. PLoS Comput Biol. 2010 Dec 2;6(12):e1001019. PubMed PMID: 21152005; PubMed Central PMCID: PMC2996318.
Kawedia JD, Kaste SC, Pei D, Panetta JC, Cai X, Cheng C, Neale G, Howard SC, Evans WE, Pui CH, Relling MV. Pharmacokinetic, pharmacodynamic and pharmacogenetic determinants of osteonecrosis in children with acute lymphoblastic leukemia. Blood. 2010 Dec 10. [Epub ahead of print] PubMed PMID: 21148812; PubMed Central PMCID: PMC3062406.
Pottier N, Paugh SW, Ding C, Pei D, Yang W, Das S, Cook EH, Pui CH, Relling MV, Cheok MH, Evans WE. Promoter polymorphisms in the β-2 adrenergic receptor are associated with drug-induced gene expression changes and response in acute lymphoblastic leukemia. Clin Pharmacol Ther. 2010 Dec;88(6):854-61. Epub 2010 Oct 27. PubMed PMID: 20981007.
Paugh SW, Stocco G, Evans WE. Pharmacogenomics in pediatric leukemia. Curr Opin Pediatr. 2010 Dec;22(6):703-10. Review. PubMed PMID: 20861736.
Zaza G, Cheok M, Krynetskaia N, Thorn C, Stocco G, Hebert JM, McLeod H, Weinshilboum RM, Relling MV, Evans WE, Klein TE, Altman RB. Thiopurine pathway. Pharmacogenet Genomics. 2010 Sep;20(9):573-4. PubMed PMID: 19952870.
Chen SH, Pei D, Yang W, Cheng C, Jeha S, Cox NJ, Evans WE, Pui CH, Relling MV. Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity. Clin Pharmacol Ther. 2010 Aug;88(2):191-6. Epub 2010 Jun 30. PubMed PMID: 20592726; PubMed Central PMCID: PMC3000799.
Relling MV, Altman RB, Goetz MP, Evans WE. Clinical implementation of pharmacogenomics: overcoming genetic exceptionalism. Lancet Oncol. 2010 Jun;11(6):507-9. Epub 2010 Apr 21. Erratum in: Lancet Oncol. 2010 Jun;11(6):516. PubMed PMID: 20413348.
Yang W, Treviño LR, Yang JJ, Scheet P, Pui CH, Evans WE, Relling MV. ARID5B SNP rs10821936 is associated with risk of childhood acute lymphoblastic leukemia in blacks and contributes to racial differences in leukemia incidence. Leukemia. 2010 Apr;24(4):894-6. Epub 2010 Jan 7. PubMed PMID: 20054350.
Stocco G, Crews KR, Evans WE. Genetic polymorphism of inosine-triphosphate-pyrophosphatase influences mercaptopurine metabolism and toxicity during treatment of acute lymphoblastic leukemia individualized for thiopurine-S-methyl-transferase status. Expert Opin Drug Saf. 2010 Jan;9(1):23-37. Review. PubMed PMID: 20021291.
Pui CH, Pei D, Sandlund JT, Ribeiro RC, Rubnitz JE, Raimondi SC, Onciu M, Campana D, Kun LE, Jeha S, Cheng C, Howard SC, Metzger ML, Bhojwani D, Downing JR, Evans WE, Relling MV. Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia. Leukemia. 2010 Feb;24(2):371-82. Epub 2009 Dec 10. PubMed PMID: 20010620; PubMed Central PMCID: PMC2820159.
Treviño LR, Shimasaki N, Yang W, Panetta JC, Cheng C, Pei D, Chan D, Sparreboom A, Giacomini KM, Pui CH, Evans WE, Relling MV. Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. J Clin Oncol. 2009 Dec 10;27(35):5972-8. Epub 2009 Nov 9. PubMed PMID: 19901119; PubMed Central PMCID: PMC2793040.
Treviño LR, Yang W, French D, Hunger SP, Carroll WL, Devidas M, Willman C, Neale G, Downing J, Raimondi SC, Pui CH, Evans WE, Relling MV. Germline genomic variants associated with childhood acute lymphoblastic leukemia. Nat Genet. 2009 Sep;41(9):1001-5. Epub 2009 Aug 16. PubMed PMID: 19684603; PubMed Central PMCID: PMC2762391.
Pui CH, Campana D, Pei D, Bowman WP, Sandlund JT, Kaste SC, Ribeiro RC, Rubnitz JE, Raimondi SC, Onciu M, Coustan-Smith E, Kun LE, Jeha S, Cheng C, Howard SC, Simmons V, Bayles A, Metzger ML, Boyett JM, Leung W, Handgretinger R, Downing JR, Evans WE, Relling MV. Treating childhood acute lymphoblastic leukemia without cranial irradiation. N Engl J Med. 2009 Jun 25;360(26):2730-41. PubMed PMID: 19553647; PubMed Central PMCID: PMC2754320.
Jeha S, Pei D, Raimondi SC, Onciu M, Campana D, Cheng C, Sandlund JT, Ribeiro RC, Rubnitz JE, Howard SC, Downing JR, Evans WE, Relling MV, Pui CH. Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1. Leukemia. 2009 Aug;23(8):1406-9. Epub 2009 Mar 12. PubMed PMID: 19282835; PubMed Central PMCID: PMC2731684.
Cheok MH, Evans WE, Kager L. High-dose methotrexate: the rationale... J Pediatr Hematol Oncol. 2009 Mar;31(3):224-5. PubMed PMID: 19262256.
Yang JJ, Cheng C, Yang W, Pei D, Cao X, Fan Y, Pounds SB, Neale G, Treviño LR, French D, Campana D, Downing JR, Evans WE, Pui CH, Devidas M, Bowman WP, Camitta BM, Willman CL, Davies SM, Borowitz MJ, Carroll WL, Hunger SP, Relling MV. Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. JAMA. 2009 Jan 28;301(4):393-403. PubMed PMID: 19176441; PubMed Central PMCID: PMC2664534.
Bauman JL, Evans WE. Pharm.D.-only investigators are critical to the profession: let's preserve the fellowship as an equally important way to prepare future clinical pharmaceutical scientists: or the case against the "all-Ph.D.". Pharmacotherapy. 2009 Feb;29(2):129-33. PubMed PMID: 19170582; PubMed Central PMCID: PMC2720311.
Den Boer ML, van Slegtenhorst M, De Menezes RX, Cheok MH, Buijs-Gladdines JG, Peters ST, Van Zutven LJ, Beverloo HB, Van der Spek PJ, Escherich G, Horstmann MA, Janka-Schaub GE, Kamps WA, Evans WE, Pieters R. A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study. Lancet Oncol. 2009 Feb;10(2):125-34. Epub 2009 Jan 8. PubMed PMID: 19138562; PubMed Central PMCID: PMC2707020.
Cheok MH, Pottier N, Kager L, Evans WE. Pharmacogenetics in acute lymphoblastic leukemia. Semin Hematol. 2009 Jan;46(1):39-51. Review. PubMed PMID: 19100367; PubMed Central PMCID: PMC2665795.
French D, Yang W, Cheng C, Raimondi SC, Mullighan CG, Downing JR, Evans WE, Pui CH, Relling MV. Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia. Blood. 2009 May 7;113(19):4512-20. Epub 2008 Dec 9. PubMed PMID: 19066393; PubMed Central PMCID: PMC2680361.
Samochatova EV, Chupova NV, Rudneva A, Makarova O, Nasedkina TV, Fedorova OE, Glotov AS, Kozhekbaeva Zh, Maiorova OA, Roumyantsev AG, Krynetski EY, Krynetskaia NF, Evans WE, Ribeiro RC. TPMT genetic variations in populations of the Russian Federation. Pediatr Blood Cancer. 2009 Feb;52(2):203-8. PubMed PMID: 19034904; PubMed Central PMCID: PMC2794198.
Hulleman E, Kazemier KM, Holleman A, VanderWeele DJ, Rudin CM, Broekhuis MJ, Evans WE, Pieters R, Den Boer ML. Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells. Blood. 2009 Feb 26;113(9):2014-21. Epub 2008 Oct 31. PubMed PMID: 18978206.
Stocco G, Cheok MH, Crews KR, Dervieux T, French D, Pei D, Yang W, Cheng C, Pui CH, Relling MV, Evans WE. Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia. Clin Pharmacol Ther. 2009 Feb;85(2):164-72. Epub 2008 Aug 6. PubMed PMID: 18685564; PubMed Central PMCID: PMC2762405.
Pottier N, Yang W, Assem M, Panetta JC, Pei D, Paugh SW, Cheng C, Den Boer ML, Relling MV, Pieters R, Evans WE, Cheok MH. The SWI/SNF chromatin-remodeling complex and glucocorticoid resistance in acute lymphoblastic leukemia. J Natl Cancer Inst. 2008 Dec 17;100(24):1792-803. Epub 2008 Dec 9. PubMed PMID: 19066270; PubMed Central PMCID: PMC2639326.
Yang JJ, Bhojwani D, Yang W, Cai X, Stocco G, Crews K, Wang J, Morrison D, Devidas M, Hunger SP, Willman CL, Raetz EA, Pui CH, Evans WE, Relling MV, Carroll WL. Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia. Blood. 2008 Nov 15;112(10):4178-83. Epub 2008 Sep 2. PubMed PMID: 18768390; PubMed Central PMCID: PMC2581992.
French D, Yang W, Hamilton LH, Neale G, Fan Y, Downing JR, Cox NJ, Pui CH, Evans WE, Relling MV. Concordant gene expression in leukemia cells and normal leukocytes is associated with germline cis-SNPs. PLoS One. 2008 May 14;3(5):e2144. PubMed PMID: 18478092; PubMed Central PMCID: PMC2374895.
Sorich MJ, Pottier N, Pei D, Yang W, Kager L, Stocco G, Cheng C, Panetta JC, Pui CH, Relling MV, Cheok MH, Evans WE. In vivo response to methotrexate forecasts outcome of acute lymphoblastic leukemia and has a distinct gene expression profile. PLoS Med. 2008 Apr 15;5(4):e83. PubMed PMID: 18416598; PubMed Central PMCID: PMC2292747.
Relling MV, Evans WE, Pui CH. Continue to study childhood ALL. Blood. 2008 Jan 1;111(1):468-9; author reply 469. PubMed PMID: 18156505; PubMed Central PMCID: PMC2200825.
Pui CH, Evans WE, Relling MV. Are children with lesser-risk B-lineage acute lymphoblastic leukemia curable with antimetabolite therapy? Nat Clin Pract Oncol. 2008 Mar;5(3):130-1. PubMed PMID: 18073720.
Pottier N, Cheok MH, Yang W, Assem M, Tracey L, Obenauer JC, Panetta JC, Relling MV, Evans WE. Expression of SMARCB1 modulates steroid sensitivity in human lymphoblastoid cells: identification of a promoter SNP that alters PARP1 binding and SMARCB1 expression. Hum Mol Genet. 2007 Oct 1;16(19):2261-71. Epub 2007 Jul 5. PubMed PMID: 17616514.
Evans WE. Creating an infrastructure for pediatric oncology drug development. Clin Adv Hematol Oncol. 2007 Mar;5(3):198-200. PubMed PMID: 17519881.
Hartford C, Vasquez E, Schwab M, Edick MJ, Rehg JE, Grosveld G, Pui CH, Evans WE, Relling MV. Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics. Cancer Res. 2007 May 15;67(10):4965-72. PubMed PMID: 17510427.
Hijiya N, Hudson MM, Lensing S, Zacher M, Onciu M, Behm FG, Razzouk BI, Ribeiro RC, Rubnitz JE, Sandlund JT, Rivera GK, Evans WE, Relling MV, Pui CH. Cumulative incidence of secondary neoplasms as a first event after childhood acute lymphoblastic leukemia. JAMA. 2007 Mar 21;297(11):1207-15. PubMed PMID: 17374815.
Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JD, Girtman K, Mathew S, Ma J, Pounds SB, Su X, Pui CH, Relling MV, Evans WE, Shurtleff SA, Downing JR. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature. 2007 Apr 12;446(7137):758-64. PubMed PMID: 17344859.
Jones TS, Yang W, Evans WE, Relling MV. Using HapMap tools in pharmacogenomic discovery: the thiopurine methyltransferase polymorphism. Clin Pharmacol Ther. 2007 May;81(5):729-34. Epub 2007 Feb 28. PubMed PMID: 17329987.
Kishi S, Cheng C, French D, Pei D, Das S, Cook EH, Hijiya N, Rizzari C, Rosner GL, Frudakis T, Pui CH, Evans WE, Relling MV. Ancestry and pharmacogenetics of antileukemic drug toxicity. Blood. 2007 May 15;109(10):4151-7. Epub 2007 Jan 30. PubMed PMID: 17264302; PubMed Central PMCID: PMC1885506.
Pui CH, Relling MV, Evans WE. Is mega dose of methotrexate beneficial to patients with acute lymphoblastic leukemia? Leuk Lymphoma. 2006 Dec;47(12):2431-2. PubMed PMID: 17169783.
Ambrosone CB, Rebbeck TR, Morgan GJ, Albain KS, Calle EE, Evans WE, Hayes DF, Kushi LH, McLeod HL, Rowland JH, Ulrich CM. New developments in the epidemiology of cancer prognosis: traditional and molecular predictors of treatment response and survival. Cancer Epidemiol Biomarkers Prev. 2006 Nov;15(11):2042-6. Review. PubMed PMID: 17119026.
Cheng Q, Cheng C, Crews KR, Ribeiro RC, Pui CH, Relling MV, Evans WE. Epigenetic regulation of human gamma-glutamyl hydrolase activity in acute lymphoblastic leukemia cells. Am J Hum Genet 2006 Aug;79(2):264-74. Epub 2006 Jun 6. Erratum in: Am J Hum Genet 2010 Jul 9;87(1):161. PubMed PMID: 16826517; PubMed Central PMCID: PMC1559484.
Kager L, Evans WE. Pharmacogenomics of acute lymphoblastic leukemia. Curr Opin Hematol. 2006 Jul;13(4):260-5. Review. PubMed PMID: 16755223.
Nasedkina TV, Fedorova OE, Glotov AS, Chupova NV, Samochatova EV, Maiorova OA, Zemlyakova VV, Roudneva AE, Chudinov AV, Yurasov RA, Kozhekbaeva JM, Barsky VE, Krynetskiy EY, Krynetskaia NF, Cheng C, Ribeiro RC, Evans WE, Roumyantsev AG, Zasedatelev AS. Rapid genotyping of common deficient thiopurine S-methyltransferase alleles using the DNA-microchip technique. Eur J Hum Genet. 2006 Sep;14(9):991-8. Epub 2006 May 17. PubMed PMID: 16724002.
Holleman A, den Boer ML, Cheok MH, Kazemier KM, Pei D, Downing JR, Janka-Schaub GE, Göbel U, Graubner UB, Pui CH, Evans WE, Pieters R. Expression of the outcome predictor in acute leukemia 1 (OPAL1) gene is not an independent prognostic factor in patients treated according to COALL or St Jude protocols. Blood. 2006 Sep 15;108(6):1984-90. Epub 2006 May 18. PubMed PMID: 16709928; PubMed Central PMCID: PMC1895531.
Evans WE. Gene expression microarrays as a prognostic test. Clin Adv Hematol Oncol. 2005 Dec;3(12):902-4. PubMed PMID: 16555428.
Cheok MH, Evans WE. Acute lymphoblastic leukaemia: a model for the pharmacogenomics of cancer therapy. Nat Rev Cancer. 2006 Feb;6(2):117-29. Review. Erratum in: Nat Rev Cancer. 2006 Mar;6(3):249. PubMed PMID: 16491071.
Eichelbaum M, Ingelman-Sundberg M, Evans WE. Pharmacogenomics and individualized drug therapy. Annu Rev Med. 2006;57:119-37. Review. PubMed PMID: 16409140.
Pui CH, Evans WE. Treatment of acute lymphoblastic leukemia. N Engl J Med. 2006 Jan 12;354(2):166-78. Review. PubMed PMID: 16407512.
Cheok MH, Lugthart S, Evans WE. Pharmacogenomics of acute leukemia. Annu Rev Pharmacol Toxicol. 2006;46:317-53. Review. PubMed PMID: 16402908.
Relling MV, Pui CH, Cheng C, Evans WE. Thiopurine methyltransferase in acute lymphoblastic leukemia. Blood. 2006 Jan 15;107(2):843-4. PubMed PMID: 16401827.
Panetta JC, Evans WE, Cheok MH. Mechanistic mathematical modelling of mercaptopurine effects on cell cycle of human acute lymphoblastic leukaemia cells. Br J Cancer. 2006 Jan 16;94(1):93-100. PubMed PMID: 16333308; PubMed Central PMCID: PMC2361089.
Cheng Q, Evans WE. Cancer pharmacogenomics may require both qualitative and quantitative approaches. Cell Cycle. 2005 Nov;4(11):1506-9. Epub 2005 Nov 8. Review. PubMed PMID: 16258271.
Pui CH, Pei D, Sandlund JT, Campana D, Ribeiro RC, Razzouk BI, Rubnitz JE, Howard SC, Hijiya N, Jeha S, Cheng C, Downing JR, Evans WE, Relling MV, Hudson M. Risk of adverse events after completion of therapy for childhood acute lymphoblastic leukemia. J Clin Oncol. 2005 Nov 1;23(31):7936-41. PubMed PMID: 16258093.
Holleman A, den Boer ML, de Menezes RX, Cheok MH, Cheng C, Kazemier KM, Janka-Schaub GE, Göbel U, Graubner UB, Evans WE, Pieters R. The expression of 70 apoptosis genes in relation to lineage, genetic subtype, cellular drug resistance, and outcome in childhood acute lymphoblastic leukemia. Blood. 2006 Jan 15;107(2):769-76. Epub 2005 Sep 27. PubMed PMID: 16189266; PubMed Central PMCID: PMC1895621.
Cheng Q, Yang W, Raimondi SC, Pui CH, Relling MV, Evans WE. Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes. Nat Genet. 2005 Aug;37(8):878-82. Epub 2005 Jul 24. PubMed PMID: 16041371.
den Boer ML, Evans WE, Pieters R. TELAML1-positive ALL: a discordant genotype. Cell Cycle. 2005 Aug;4(8):997-8. Epub 2005 Aug 23. PubMed PMID: 15970674.
Zaza G, Cheok M, Yang W, Panetta JC, Pui CH, Relling MV, Evans WE. Gene expression and thioguanine nucleotide disposition in acute lymphoblastic leukemia after in vivo mercaptopurine treatment. Blood. 2005 Sep 1;106(5):1778-85. Epub 2005 May 19. PubMed PMID: 15905191; PubMed Central PMCID: PMC1895216.
French D, Wilkinson MR, Yang W, de Chaisemartin L, Cook EH, Das S, Ratain MJ, Evans WE, Downing JR, Pui CH, Relling MV. Global gene expression as a function of germline genetic variation. Hum Mol Genet. 2005 Jun 15;14(12):1621-9. Epub 2005 Apr 27. PubMed PMID: 15857854.
Lugthart S, Cheok MH, den Boer ML, Yang W, Holleman A, Cheng C, Pui CH, Relling MV, Janka-Schaub GE, Pieters R, Evans WE. Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia. Cancer Cell. 2005 Apr;7(4):375-86. PubMed PMID: 15837626.
Stams WA, den Boer ML, Holleman A, Appel IM, Beverloo HB, van Wering ER, Janka-Schaub GE, Evans WE, Pieters R. Asparagine synthetase expression is linked with L-asparaginase resistance in TEL-AML1-negative but not TEL-AML1-positive pediatric acute lymphoblastic leukemia. Blood. 2005 Jun 1;105(11):4223-5. Epub 2005 Feb 17. PubMed PMID: 15718422.
Rocha JC, Cheng C, Liu W, Kishi S, Das S, Cook EH, Sandlund JT, Rubnitz J, Ribeiro R, Campana D, Pui CH, Evans WE, Relling MV. Pharmacogenetics of outcome in children with acute lymphoblastic leukemia. Blood. 2005 Jun 15;105(12):4752-8. Epub 2005 Feb 15. PubMed PMID: 15713801; PubMed Central PMCID: PMC1895006.
Kager L, Cheok M, Yang W, Zaza G, Cheng Q, Panetta JC, Pui CH, Downing JR, Relling MV, Evans WE. Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics. J Clin Invest. 2005 Jan;115(1):110-7. PubMed PMID: 15630450; PubMed Central PMCID: PMC539195.
Rivera GK, Zhou Y, Hancock ML, Gajjar A, Rubnitz J, Ribeiro RC, Sandlund JT, Hudson M, Relling M, Evans WE, Pui CH. Bone marrow recurrence after initial intensive treatment for childhood acute lymphoblastic leukemia. Cancer. 2005 Jan 15;103(2):368-76. PubMed PMID: 15599932.
Tognoni G, Masera G, Pui CH, Eden T, Nachman J, Gadner H, Gaynon PS, Evans WE, Schrappe M. Statement by members of the Ponte di Legno group on the right of children with leukemia to have full access to essential treatment for acute lymphoblastic leukemia. Ann Oncol. 2005 Jan;16(1):169-70. PubMed PMID: 15598956.
Petros WP, Evans WE. Pharmacogenomics in cancer therapy: is host genome variability important? Trends Pharmacol Sci. 2004 Sep;25(9):457-64. Review. PubMed PMID: 15559247.
Edick MJ, Cheng C, Yang W, Cheok M, Wilkinson MR, Pei D, Evans WE, Kun LE, Pui CH, Relling MV. Lymphoid gene expression as a predictor of risk of secondary brain tumors. Genes Chromosomes Cancer. 2005 Feb;42(2):107-16. PubMed PMID: 15543619.
Holleman A, Cheok MH, den Boer ML, Yang W, Veerman AJ, Kazemier KM, Pei D, Cheng C, Pui CH, Relling MV, Janka-Schaub GE, Pieters R, Evans WE. Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment. N Engl J Med. 2004 Aug 5;351(6):533-42. PubMed PMID: 15295046.
Cheng Q, Wu B, Kager L, Panetta JC, Zheng J, Pui CH, Relling MV, Evans WE. A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells. Pharmacogenetics. 2004 Aug;14(8):557-67. PubMed PMID: 15284538.
Pui CH, Sandlund JT, Pei D, Campana D, Rivera GK, Ribeiro RC, Rubnitz JE, Razzouk BI, Howard SC, Hudson MM, Cheng C, Kun LE, Raimondi SC, Behm FG, Downing JR, Relling MV, Evans WE; Total Therapy Study XIIIB at St Jude Children's Research Hospital. Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children's Research Hospital. Blood. 2004 Nov 1;104(9):2690-6. Epub 2004 Jul 13. PubMed PMID: 15251979.
Masera G, Eden T, Schrappe M, Nachman J, Gadner H, Gaynon P, Evans WE, Pui CH; Ponte di Legno Group. Statement by members of the Ponte di Legno Group on the right of children to have full access to essential treatment for acute lymphoblastic leukemia. Pediatr Blood Cancer. 2004 Aug;43(2):103-4. PubMed PMID: 15236273.
Evans WE. Pharmacogenetics of thiopurine S-methyltransferase and thiopurine therapy. Ther Drug Monit. 2004 Apr;26(2):186-91. Review. PubMed PMID: 15228163.
Krynetskiy EY, Evans WE. Closing the gap between science and clinical practice: the thiopurine S-methyltransferase polymorphism moves forward. Pharmacogenetics. 2004 Jul;14(7):395-6. Review. PubMed PMID: 15226671.
Evans WE, Relling MV. Moving towards individualized medicine with pharmacogenomics. Nature. 2004 May 27;429(6990):464-8. Review. PubMed PMID: 15164072.
Zaza G, Yang W, Kager L, Cheok M, Downing J, Pui CH, Cheng C, Relling MV, Evans WE. Acute lymphoblastic leukemia with TEL-AML1 fusion has lower expression of genes involved in purine metabolism and lower de novo purine synthesis. Blood. 2004 Sep 1;104(5):1435-41. Epub 2004 May 13. PubMed PMID: 15142881.
Pui CH, Relling MV, Sandlund JT, Downing JR, Campana D, Evans WE. Rationale and design of Total Therapy Study XV for newly diagnosed childhood acute lymphoblastic leukemia. Ann Hematol. 2004;83 Suppl 1:S124-6. PubMed PMID: 15124703.
Pui CH, Schrappe M, Masera G, Nachman J, Gadner H, Eden OB, Evans WE, Gaynon P; Ponte di Legno Working Group. Ponte di Legno Working Group: statement on the right of children with leukemia to have full access to essential treatment and report on the Sixth International Childhood Acute Lymphoblastic Leukemia Workshop. Leukemia. 2004 Jun;18(6):1043-53. PubMed PMID: 15085155.
Evans WE, Guy RK. Gene expression as a drug discovery tool. Nat Genet. 2004 Mar;36(3):214-5. PubMed PMID: 14988717.
Brown VM, Krynetski EY, Krynetskaia NF, Grieger D, Mukatira ST, Murti KG, Slaughter CA, Park HW, Evans WE. A novel CRM1-mediated nuclear export signal governs nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase following genotoxic stress. J Biol Chem. 2004 Feb 13;279(7):5984-92. Epub 2003 Nov 14. PubMed PMID: 14617633.
Krynetski E, Evans WE. Drug methylation in cancer therapy: lessons from the TPMT polymorphism. Oncogene. 2003 Oct 20;22(47):7403-13. Review. PubMed PMID: 14576848.
Pui CH, Sandlund JT, Pei D, Rivera GK, Howard SC, Ribeiro RC, Rubnitz JE, Razzouk BI, Hudson MM, Cheng C, Raimondi SC, Behm FG, Downing JR, Relling MV, Evans WE. Results of therapy for acute lymphoblastic leukemia in black and white children. JAMA. 2003 Oct 15;290(15):2001-7. PubMed PMID: 14559953.
Pui CH, Cheng C, Leung W, Rai SN, Rivera GK, Sandlund JT, Ribeiro RC, Relling MV, Kun LE, Evans WE, Hudson MM. Extended follow-up of long-term survivors of childhood acute lymphoblastic leukemia. N Engl J Med. 2003 Aug 14;349(7):640-9. Erratum in: N Engl J Med. 2003 Sep 25;349(13):1299. PubMed PMID: 12917300.
Krynetskaia NF, Brenner TL, Krynetski EY, Du W, Panetta JC, Ching-Hon P, Evans WE. Msh2 deficiency attenuates but does not abolish thiopurine hematopoietic toxicity in msh2-/- mice. Mol Pharmacol. 2003 Aug;64(2):456-65. PubMed PMID: 12869651.
Dervieux T, Hancock ML, Pui CH, Rivera GK, Sandlund JT, Ribeiro RC, Boyett J, Evans WE, Relling MV. Antagonism by methotrexate on mercaptopurine disposition in lymphoblasts during up-front treatment of acute lymphoblastic leukemia. Clin Pharmacol Ther. 2003 Jun;73(6):506-16. PubMed PMID: 12811360.
Cheok MH, Yang W, Pui CH, Downing JR, Cheng C, Naeve CW, Relling MV, Evans WE. Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells. Nat Genet. 2003 May;34(1):85-90. Erratum in: Nat Genet. 2003 Jun;34(2):231. PubMed PMID: 12704389.
Pui CH, Chessells JM, Camitta B, Baruchel A, Biondi A, Boyett JM, Carroll A, Eden OB, Evans WE, Gadner H, Harbott J, Harms DO, Harrison CJ, Harrison PL, Heerema N, Janka-Schaub G, Kamps W, Masera G, Pullen J, Raimondi SC, Richards S, Riehm H, Sallan S, Sather H, Shuster J, Silverman LB, Valsecchi MG, Vilmer E, Zhou Y, Gaynon PS, Schrappe M. Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements. Leukemia. 2003 Apr;17(4):700-6. Review. PubMed PMID: 12682627.
Evans WE. Pharmacogenomics: marshalling the human genome to individualise drug therapy. Gut. 2003 May;52 Suppl 2:ii10-8. Review. PubMed PMID: 12651877; PubMed Central PMCID: PMC1867751.
Evans WE, Cheok M, Yang W, Sherr CJ. Expression arrays illuminate a way forward for mantle cell lymphoma. Cancer Cell. 2003 Feb;3(2):100-2. PubMed PMID: 12620403.
Pui CH, Relling MV, Evans WE. Role of pharmacogenomics and pharmacodynamics in the treatment of acute lymphoblastic leukaemia. Best Pract Res Clin Haematol. 2002 Dec;15(4):741-56. Review. PubMed PMID: 12617874.
Evans WE, McLeod HL. Pharmacogenomics--drug disposition, drug targets, and side effects. N Engl J Med. 2003 Feb 6;348(6):538-49. PubMed PMID: 12571262.
Relling MV, Boyett JM, Blanco JG, Raimondi S, Behm FG, Sandlund JT, Rivera GK, Kun LE, Evans WE, Pui CH. Granulocyte colony-stimulating factor and the risk of secondary myeloid malignancy after etoposide treatment. Blood. 2003 May 15;101(10):3862-7. Epub 2003 Jan 16. PubMed PMID: 12531808.
Krynetski EY, Krynetskaia NF, Bianchi ME, Evans WE. A nuclear protein complex containing high mobility group proteins B1 and B2, heat shock cognate protein 70, ERp60, and glyceraldehyde-3-phosphate dehydrogenase is involved in the cytotoxic response to DNA modified by incorporation of anticancer nucleoside analogues. Cancer Res. 2003 Jan 1;63(1):100-6. PubMed PMID: 12517784.
Panetta JC, Yanishevski Y, Pui CH, Sandlund JT, Rubnitz J, Rivera GK, Ribeiro R, Evans WE, Relling MV. A mathematical model of in vivo methotrexate accumulation in acute lymphoblastic leukemia. Cancer Chemother Pharmacol. 2002 Nov;50(5):419-28. Epub 2002 Sep 24. PubMed PMID: 12439601.
Somerville L, Krynetski EY, Krynetskaia NF, Beger RD, Zhang W, Marhefka CA, Evans WE, Kriwacki RW. Structure and dynamics of thioguanine-modified duplex DNA. J Biol Chem. 2003 Jan 10;278(2):1005-11. Epub 2002 Oct 24. PubMed PMID: 12401802.
Broder S, Caplan A, Evans WE. Therapeutic horizons--the human genome. J Am Pharm Assoc (Wash). 2002 Sep-Oct;42(5 Suppl 1):S22-3. PubMed PMID: 12296540.
Pui CH, Relling MV, Campana D, Evans WE. Childhood acute lymphoblastic leukemia. Rev Clin Exp Hematol. 2002 Jun;6(2):161-80; discussion 200-2. PubMed PMID: 12196214.
Evans WE. Thiopurine S-methyltransferase: a genetic polymorphism that affects a small number of drugs in a big way. Pharmacogenetics. 2002 Aug;12(6):421-3. PubMed PMID: 12172209.
Dervieux T, Brenner TL, Hon YY, Zhou Y, Hancock ML, Sandlund JT, Rivera GK, Ribeiro RC, Boyett JM, Pui CH, Relling MV, Evans WE. De novo purine synthesis inhibition and antileukemic effects of mercaptopurine alone or in combination with methotrexate in vivo. Blood. 2002 Aug 15;100(4):1240-7. PubMed PMID: 12149204.
Evans WE. Comprehensive assessment of thiopurine S-methyltransferase (TPMT) alleles in three ethnic populations. J Pediatr Hematol Oncol. 2002 Jun-Jul;24(5):335-6. PubMed PMID: 12142779.
Panetta JC, Wall A, Pui CH, Relling MV, Evans WE. Methotrexate intracellular disposition in acute lymphoblastic leukemia: a mathematical model of gamma-glutamyl hydrolase activity. Clin Cancer Res. 2002 Jul;8(7):2423-9. PubMed PMID: 12114448.
Leung W, Rose SR, Zhou Y, Hancock ML, Burstein S, Schriock EA, Lustig R, Danish RK, Evans WE, Hudson MM, Pui CH. Outcomes of growth hormone replacement therapy in survivors of childhood acute lymphoblastic leukemia. J Clin Oncol. 2002 Jul 1;20(13):2959-64. PubMed PMID: 12089225.
Yeoh EJ, Ross ME, Shurtleff SA, Williams WK, Patel D, Mahfouz R, Behm FG, Raimondi SC, Relling MV, Patel A, Cheng C, Campana D, Wilkins D, Zhou X, Li J, Liu H, Pui CH, Evans WE, Naeve C, Wong L, Downing JR. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell. 2002 Mar;1(2):133-43. PubMed PMID: 12086872.
Johnson JA, Evans WE. Molecular diagnostics as a predictive tool: genetics of drug efficacy and toxicity. Trends Mol Med. 2002 Jun;8(6):300-5. Review. PubMed PMID: 12067617.
Ramakers-van Woerden NL, Pieters R, Rots MG, van Zantwijk CH, Noordhuis P, Beverloo HB, Peters GJ, van Wering ER, Camitta BM, Pui CH, Relling MV, Evans WE, Veerman AJ. Infants with acute lymphoblastic leukemia: no evidence for high methotrexate resistance. Leukemia. 2002 May;16(5):949-51. PubMed PMID: 11986959.
Evans WE. Differing effects of methylenetetrahydrofolate reductase single nucleotide polymorphisms on methotrexate efficacy and toxicity in rheumatoid arthritis. Pharmacogenetics. 2002 Apr;12(3):181-2. PubMed PMID: 11927832.
McDonald OG, Krynetski EY, Evans WE. Molecular haplotyping of genomic DNA for multiple single-nucleotide polymorphisms located kilobases apart using long-range polymerase chain reaction and intramolecular ligation. Pharmacogenetics. 2002 Mar;12(2):93-9. PubMed PMID: 11875363.
Dervieux T, Chu Y, Su Y, Pui CH, Evans WE, Relling MV. HPLC determination of thiopurine nucleosides and nucleotides in vivo in lymphoblasts following mercaptopurine therapy. Clin Chem. 2002 Jan;48(1):61-8. PubMed PMID: 11751539.
Pui CH, Campana D, Evans WE. Childhood acute lymphoblastic leukaemia--current status and future perspectives. Lancet Oncol. 2001 Oct;2(10):597-607. Review. PubMed PMID: 11902549.
Leung W, Sandlund JT, Hudson MM, Zhou Y, Hancock ML, Zhu Y, Ribeiro RC, Rubnitz JE, Kun LE, Razzouk B, Evans WE, Pui CH. Second malignancy after treatment of childhood non-Hodgkin lymphoma. Cancer. 2001 Oct 1;92(7):1959-66. PubMed PMID: 11745271.
Evans WE, Ingelman-Sundberg M. Resequencing the sulfotransferase SULT1 gene provides new insights, while illuminating challenges that lie ahead for pharmacogenomics. Pharmacogenetics. 2001 Dec;11(9):745-6. PubMed PMID: 11740337.
Evans WE, Johnson JA. Pharmacogenomics: the inherited basis for interindividual differences in drug response. Annu Rev Genomics Hum Genet. 2001;2:9-39. Review. PubMed PMID: 11701642.
Ingelman-Sundberg M, Evans WE. Unravelling the functional genomics of the human CYP2D6 gene locus. Pharmacogenetics. 2001 Oct;11(7):553-4. PubMed PMID: 11668215.
Krynetskaia NF, Feng JY, Krynetski EY, Garcia JV, Panetta JC, Anderson KS, Evans WE. Deoxythioguanosine triphosphate impairs HIV replication: a new mechanism for an old drug. FASEB J. 2001 Sep;15(11):1902-8. PubMed PMID: 11532970.
Pui CH, Sallan S, Relling MV, Masera G, Evans WE. International Childhood Acute Lymphoblastic Leukemia Workshop: Sausalito, CA, 30 November-1 December 2000. Leukemia. 2001 May;15(5):707-15. PubMed PMID: 11368430.
Evans WE, Hon YY, Bomgaars L, Coutre S, Holdsworth M, Janco R, Kalwinsky D, Keller F, Khatib Z, Margolin J, Murray J, Quinn J, Ravindranath Y, Ritchey K, Roberts W, Rogers ZR, Schiff D, Steuber C, Tucci F, Kornegay N, Krynetski EY, Relling MV. Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine. J Clin Oncol. 2001 Apr 15;19(8):2293-301. PubMed PMID: 11304783.
McLeod HL, Evans WE. Pharmacogenomics: unlocking the human genome for better drug therapy. Annu Rev Pharmacol Toxicol. 2001;41:101-21. Review. PubMed PMID: 11264452.
Leung W, Ribeiro RC, Hudson M, Tong X, Srivastava DK, Rubnitz JE, Sandlund JT, Razzouk BI, Evans WE, Pui CH. Second malignancy after treatment of childhood acute myeloid leukemia. Leukemia. 2001 Jan;15(1):41-5. PubMed PMID: 11243397.
Krynetski EY, Krynetskaia NF, Gallo AE, Murti KG, Evans WE. A novel protein complex distinct from mismatch repair binds thioguanylated DNA. Mol Pharmacol. 2001 Feb;59(2):367-74. PubMed PMID: 11160874.
Pui CH, Boyett JM, Rivera GK, Hancock ML, Sandlund JT, Ribeiro RC, Rubnitz JE, Behm FG, Raimondi SC, Gajjar A, Razzouk B, Campana D, Kun LE, Relling MV, Evans WE. Long-term results of Total Therapy studies 11, 12 and 13A for childhood acute lymphoblastic leukemia at St Jude Children's Research Hospital. Leukemia. 2000 Dec;14(12):2286-94. PubMed PMID: 11187920.
Gajjar A, Harrison PL, Sandlund JT, Rivera GK, Ribeiro RC, Rubnitz JE, Razzouk B, Relling MV, Evans WE, Boyett JM, Pui CH. Traumatic lumbar puncture at diagnosis adversely affects outcome in childhood acute lymphoblastic leukemia. Blood. 2000 Nov 15;96(10):3381-4. PubMed PMID: 11071631.
Relling MV, Pui CH, Sandlund JT, Rivera GK, Hancock ML, Boyett JM, Schuetz EG, Evans WE. Adverse effect of anticonvulsants on efficacy of chemotherapy for acute lymphoblastic leukaemia. Lancet. 2000 Jul 22;356(9226):285-90. PubMed PMID: 11071183.
Leung W, Hudson MM, Strickland DK, Phipps S, Srivastava DK, Ribeiro RC, Rubnitz JE, Sandlund JT, Kun LE, Bowman LC, Razzouk BI, Mathew P, Shearer P, Evans WE, Pui CH. Late effects of treatment in survivors of childhood acute myeloid leukemia. J Clin Oncol. 2000 Sep 15;18(18):3273-9. PubMed PMID: 10986060.
Krynetski EY, Evans WE. Genetic polymorphism of thiopurine S-methyltransferase: molecular mechanisms and clinical importance. Pharmacology. 2000 Sep;61(3):136-46. Review. PubMed PMID: 10971199.
Leung W, Hudson M, Zhu Y, Rivera GK, Ribeiro RC, Sandlund JT, Bowman LC, Evans WE, Kun L, Pui CH. Late effects in survivors of infant leukemia. Leukemia. 2000 Jul;14(7):1185-90. PubMed PMID: 10914540.
Pui CH, Raimondi SC, Srivastava DK, Tong X, Behm FG, Razzouk B, Rubnitz JE, Sandlund JT, Evans WE, Ribeiro R. Prognostic factors in infants with acute myeloid leukemia. Leukemia. 2000 Apr;14(4):684-7. PubMed PMID: 10764155.
McLeod HL, Krynetski EY, Relling MV, Evans WE. Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia. Leukemia. 2000 Apr;14(4):567-72. Review. PubMed PMID: 10764140.
Woo MH, Hak LJ, Storm MC, Sandlund JT, Ribeiro RC, Rivera GK, Rubnitz JE, Harrison PL, Wang B, Evans WE, Pui CH, Relling MV. Hypersensitivity or development of antibodies to asparaginase does not impact treatment outcome of childhood acute lymphoblastic leukemia. J Clin Oncol. 2000 Apr;18(7):1525-32. PubMed PMID: 10735901.
Blanco JG, Harrison PL, Evans WE, Relling MV. Human cytochrome P450 maximal activities in pediatric versus adult liver. Drug Metab Dispos. 2000 Apr;28(4):379-82. PubMed PMID: 10725303.