To download a PDF version of the paper or supplemental materials, click on the link.
1988
-
Guo L, Su Z, Luo Z, Chen T, Luan Y, Pu X. Malignant transformation increases the sensitivity of cells to parvoviruses. Chinese J. Cell Biol. 10: 125-130, 1988.
1991
Luo Z, Chen T, Yan S, Wang S, Liu W, Wang J, Sun J. Protein sequence homology comparison of viral proteins and oncoproteins as an evidence for the lack of oncogenic potency in parvoviruses. J. Fudan University (Natural Science) 30: 405-412, 1991.
1993
Luo Z, Ma C, Chen T, Guo L, Lin W. History and present status of research on the antineoplastic activity of parvoviruses (Review). J. Fudan University (Natural Science) 32: 85-92, 1993.
1997
Chen T, Kurjan J. Saccharomyces cerevisiae Mpt5p interacts with Sst2p and plays roles in pheromone sensitivity and recovery from pheromone arrest. Mol Cell Biol 17: 3429-3439, 1997.
1999
Gao Z, Chen T, Weber MJ, Linden J. A2B adenosine and P2Y2 receptors stimulate mitogen-activated protein kinase in human embryonic kidney-293 cells. Cross-talk between cyclic AMP and protein kinase C pathways. J Biol Chem 274: 5972-5980, 1999.
Chen T, Cho RW, Stork PJ, Weber MJ. Elevation of cyclic adenosine 3’,5’-monophosphate potentiates activation of mitogen-activated protein kinase by growth factors in LNCaP prostate cancer cells. Cancer Res 59: 213-218, 1999.
Gao Z, Chen T, Weber MJ, Linden J. A2B adenosine and P2Y2 receptors stimulate mitogen-activated protein kinase in human embryonic kidney-293 cells. Cross-talk between cyclic AMP and protein kinase C pathways. J Biol Chem 274: 5972-5980, 1999.
2000
Yang XY, Wang LH, Chen T, Hodge DR, Resau JH, DaSilva L, Farrar WL. Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. J Biol Chem 275: 4541-4544, 2000.
Chen T (corresponding author), Wang L, Farrar WL. Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells. Cancer Res 60: 2132-2135, 2000.
2001
Xiao W, Wang L, Yang XY, Chen T, Hodge D, Johnson PF, Farrar W. CCAAT/enhancer-binding protein beta (CEBP-beta) mediates interferon-gamma-induced P48 (ISGF3-gamma) gene transcription in human monocytic cells. J Biol Chem 276: 23275-23281, 2001.
2002
Yang XY, Wang LH, Mihalic K, Xiao W, Chen T, Li P, Wahl LM, Farrar WL. Interleukin (IL)-4 indirectly suppresses IL-2 production by human T lymphocytes via peroxisome proliferator-activated receptor gamma activated by macrophage-derived 12/15-lipoxygenase ligands. J Biol Chem 277: 3973-3978, 2002.
2003
Chen T (corresponding author), Xie W, Agler M, Banks M. Coactivators in assay design for nuclear hormone receptor drug discovery. Assay Drug Dev Technol 6: 835-842, 2003.
2004
Zhu Z, Kim S, Chen T, Lin JH, Bell A, Bryson J, Dubaquie Y, Yan N, Yanchunas J, Xie D, Stoffel R, Sinz M, Dickinson K. Correlation of high-throughput pregnane X receptor (PXR) transactivation and binding assays. J Biomol Screen 9: 533-540, 2004.
2005
Chen T (corresponding author), Hansen G, Beske O, Yates K, Zhu Y, Anthony M, Agler M, Banks M. Analysis of cellular events using CellCard System in cell-based high-content multiplexed assays. Expert Rev Mol Diagn 5: 817-829, 2005.
Gong H, Sinz MW, Feng Y, Chen T, Venkataramanan R, Xie W. Animal models of xenobiotic receptors in drug metabolism and diseases. Methods Enzymol 400: 598-618, 2005.
2006
Sinz M, Kim S, Zhu Z, Chen T, Anthony M, Dickinson K, Rodrigues AD. Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions. Curr Drug Metab 7: 375-388, 2006.
Chen T (co-corresponding author), Feng X. Cell-based assay strategy for identification of motif-specific RANK signaling pathway inhibitors. Assay Drug Dev Technol 4: 473-482, 2006.
Chen T (corresponding author), Knapp AC, Wu Y, Huang J, Lynch JS, Dickson JK Jr., Lawrence RM, Feyen JH, Agler ML. High throughput screening identified a substituted imidazole as a novel RANK pathway selective osteoclastogenesis inhibitor. Assay Drug Dev Technol 4: 387-396, 2006.
2007
Agler M, Prack M, Zhu Y, Kolb J, Nowak K, Ryseck R, Shen D, Cvijic ME, Somerville J, Nadler S, Chen T. A high-content glucocorticoid receptor translocation assay for compound mechanism-of-action evaluation. J Biomol Screen 12: 1029-1041, 2007.
2008
Chen T. Nuclear receptor drug discovery. Curr Opin Chem Biol 12: 418-426, 2008.
Lin W, Wu J, Dong H, Bouck D, Zeng FY, Chen T. Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. J Biol Chem 283: 30650-30657, 2008.
2009
Pondugula SR, Brimer-Cline C, Wu J, Schuetz EG, Tyagi RK, Chen T. A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane X receptor. Drug Metab Dispos 37: 719-730, 2009.
Mu Q, Du G, Chen T, Zhang B, Yan B. Suppression of human bone morphogenetic protein signaling by carboxylated single-walled carbon nanotubes. ACS Nano 3: 1139-1144, 2009.
Zeng FY, Cui J, Liu L, Chen T. PAX3-FKHR sensitizes human alveolar rhabdomyosarcoma cells to camptothecin-mediated growth inhibition and apoptosis. Cancer Lett 284: 157-164, 2009.
Pondugula SR, Dong H, Chen T. Phosphorylation and protein-protein interactions in PXR-mediated CYP3A repression. Expert Opin Drug Metab Toxicol 5: 861-873, 2009.
Herbst J, Anthony M, Stewart J, Connors D, Chen T, Banks M, Petrillo EW, Agler M. Multiplexing a high-throughput liability assay to leverage efficiencies. Assay Drug Dev Technol 7: 294-303, 2009.
2010
Zeng FY, Dong H, Cui J, Liu L, Chen T. Glycogen synthase kinase 3 regulates PAX3-FKHR-mediated cell proliferation in human alveolar rhabdomyosarcoma cells. Biochem Biophys Res Commun 391: 1049-1055, 2010.
Dong H, Lin W, Wu J, Chen T. Flavonoids activate pregnane X receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells. BMC Biochem 11:23, 2010.
Pondugula SR, Tong AA, Wu J, Cui J, Chen T. Protein phosphatase 2Cβl regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. Drug Metab Dispos 38: 1411-1416, 2010.
Leonardi R, Zhang Y-M, Yun M-K, Zhou R, Zeng F-Y, Lin W, Cui J, Chen T, Rock CO, White SW, Jackowski S. Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain. Chem Biol 17: 892-902, 2010.
Chen T. Overcoming drug resistance by regulating nuclear receptors. Adv Drug Deliv Rev, 62:1257-1264, 2010.
Pondugula SR, Xie W, Chen T. PXR and hepatocyte proliferation. J Exp Clin Med 2: 260-261, 2010.
Young BM;Hyatt JL;Bouck DC;Chen T;Hanumesh P;Price J;Boyd VA;Potter PM;Webb TR; Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2-ethanediones: potent, selective carboxylesterase inhibitors. J Med Chem 53 (24):8709-8715 2010
2011
Zhao Y, Hammoudeh D, Lin W, Das S, Yun MK, Li Z, Griffith E, Chen T, White SW, Lee RE. Development of a pterin-based fluorescent probe for screening dihydropteroate synthase. Bioconjug Chem September 30, 2011.
-
Cui J, Chai SC, Shelat AA, Guy RK, Chen T. An automated approach to efficiently reformat a large collection of compounds. Curr Chem Genomics 5:42-47, 2011.
-
Bouck DC, Shu P, Cui J, Shelat A, Chen T. A high-content screen identifies inhibitors of nuclear export of forkhead transcription factors. J Biomol Screen 16(4):394-404, 2011.
Ashley JW, McCoy EM, Clements DA, Shi Z, Chen T, Feng X. Development of cell-based high-throughput assays for the identification of inhibitors of receptor activator of nuclear factor-kappa B signaling. Assay Drug Dev Technol 9(1):40-49, 2011.