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Chen Lab: About Us

Welcome to the lab of Taosheng Chen, PhD, PMP

Back Row, Left to Right: Jing Wu, Sergio Chai, Monimoy Banerjee (former),Yueming Wang, Taosheng Chen, Changhui Liu (former), Jordan Beard, Jesse Bakke, Alexa Tenga
Front Row, Left to Right: Chen Zhang, Jonathan Low, Wenwei Lin, Asli Goktug (former), Duane Currier, Colins Eno (former), Trent Brewer, Delira Robbins (former), Ayesha Elias (former), Yanfeng Li, Ray Hefner

Research activities in the Chen laboratory focus on the regulation of the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) in drug toxicity and resistance. In addition, we are studying the roles of PAX3-FOXO1 and impaired muscle differentiation in the development of rhabdomyosarcoma. We seek to discover and develop novel pharmacological tools and therapeutic agents that will help prevent drug toxicity, attenuate drug resistance, and treat cancer.

In addition to cellular, molecular, biochemical, genomic, and proteomic techniques and animal models, we also take advantage of our unique technology platforms for small molecules (>‚ÄČ800,000 compounds) and RNA interference (whole genome), facilitated by laboratory automation and high-throughput and high-content screening, to accelerate our research (See “HTB Center” for details).