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Supplementary Information

Gene Expression Profiling of Pediatric Acute Myelogenous Leukemia

Section IV: MLL in combined ALL and AML dataset

Table S14. Class discriminating genes for cases with an MLL chimeric fusion gene that show uniform high expression, irrespective of blast lineage

  U133 probe set Gene description Symbol Location GenBank reference UniGene reference Ranka Fold change vs. CD34b p = 0.001c
1 204069_at Meis1, myeloid ecotropic viral integration site 1 homolog (mouse) MEIS1 Chr:2p14-p13 NM_002398 Hs.170177 1 1.0  
2 201153_s_at muscleblind-like (Drosophila) MBNL1 Chr:3q25 NM_021038 Hs.28578 2 1.4  
3 214651_s_at homeo box A9 HOXA9 Chr:7p15-p14 U41813 Hs.127428 4 3.5 *
4 201850_at capping protein (actin filament), gelsolin-like CAPG Chr:2cen-q24 NM_001747 Hs.82422 7 6.5 *
5 213147_at homeo box A10 HOXA10 Chr:7p15-p14 AI375919 Hs.110637 10 2.4 *
6 206847_s_at homeo box A7 HOXA7 Chr:7p15-p14 AF026397 Hs.446318 11 1.4  
7 218376_s_at NEDD9 interacting protein with calponin homology and LIM domains NICAL Chr:6q21 NM_022765 Hs.33476 15 3.4 *
8 213844_at homeo box A5 HOXA5 Chr:7p15-p14 NM_019102 Hs.37034 16 2.5  
9 211733_x_at sterol carrier protein 2 SCP2 Chr:1p32 BC005911 Hs.75760 17 1.0  
10 204824_at endonuclease G ENDOG Chr:9q34.1 NM_004435 Hs.420106 19 1.6  
11 204839_at RNase MRP/RNase P protein-like POP5 Chr:12q24.31 NM_015918 Hs.279913 35 0.9  
12 219577_s_at ATP-binding cassette, sub-family A (ABC1), member 7 ABCA7 Chr:19p13.3 NM_019112 Hs.134514 36 2.4 *
13 206289_at homeo box A4 HOXA4 Chr:7p15-p14 NM_002141 Hs.147747 41 1.8  
14 211926_s_at myosin, heavy polypeptide 9, non-muscle MYH9 Chr:22q13.1 AI827941 Hs.146550 48 2.6 *
15 200897_s_at palladin KIAA0992 Chr:4q32.3 NM_016081 Hs.194431 52 2.1  
16 209822_s_at very low density lipoprotein receptor VLDLR Chr:9p24 L22431 Hs.370422 57 6.1 *
17 208679_s_at actin related protein 2/3 complex, subunit 2, 34kDa ARPC2 Chr:2q36.1 AF279893 Hs.83583 67 1.6 *
18 212588_at protein tyrosine phosphatase, receptor type, C PTPRC Chr:1q31-q32 Y00062 Hs.444324 69 1.5 *
19 201818_at hypothetical protein FLJ12443 FLJ12443 Chr:5p15.33 NM_024830 Hs.179882 77 1.2  
20 201705_at proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog) PSMD7 Chr:16q23-q24 NM_002811 Hs.440604 92 1.0  
21 207419_s_at ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) RAC2 Chr:22q13.1 NM_002872 Hs.301175 98 2.1 *

aIndicated rankings correspond to those shown in Table S13.
b
Fold change was calculated as the ratio of the mean signal in cases containing MLL chimeric fusion gene to mean signal of sorted  normal bone marrow CD34+ cells (n=4).
C
an * marks genes with a fold change that was statistically significant at a level of p≤ 0.001 by a t-test.