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Evans, William, PharmD

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Veerman, Anjo J. P.

St. Jude Research >> AML1 >> SectionIV >> Table_s14

Supplementary Information

Gene Expression Profiling of Pediatric Acute Myelogenous Leukemia

Section IV: MLL in combined ALL and AML dataset

Table S14. Class discriminating genes for cases with an MLL chimeric fusion gene that show uniform high expression, irrespective of blast lineage

	U133 probe set	Gene description	Symbol	Location	GenBank reference	UniGene reference	Rank^a	Fold change vs. CD34^b	p = 0.001^c
1	204069_at	Meis1, myeloid ecotropic viral integration site 1 homolog (mouse)	MEIS1	Chr:2p14-p13	NM_002398	Hs.170177	1	1.0
2	201153_s_at	muscleblind-like (Drosophila)	MBNL1	Chr:3q25	NM_021038	Hs.28578	2	1.4
3	214651_s_at	homeo box A9	HOXA9	Chr:7p15-p14	U41813	Hs.127428	4	3.5	*
4	201850_at	capping protein (actin filament), gelsolin-like	CAPG	Chr:2cen-q24	NM_001747	Hs.82422	7	6.5	*
5	213147_at	homeo box A10	HOXA10	Chr:7p15-p14	AI375919	Hs.110637	10	2.4	*
6	206847_s_at	homeo box A7	HOXA7	Chr:7p15-p14	AF026397	Hs.446318	11	1.4
7	218376_s_at	NEDD9 interacting protein with calponin homology and LIM domains	NICAL	Chr:6q21	NM_022765	Hs.33476	15	3.4	*
8	213844_at	homeo box A5	HOXA5	Chr:7p15-p14	NM_019102	Hs.37034	16	2.5
9	211733_x_at	sterol carrier protein 2	SCP2	Chr:1p32	BC005911	Hs.75760	17	1.0
10	204824_at	endonuclease G	ENDOG	Chr:9q34.1	NM_004435	Hs.420106	19	1.6
11	204839_at	RNase MRP/RNase P protein-like	POP5	Chr:12q24.31	NM_015918	Hs.279913	35	0.9
12	219577_s_at	ATP-binding cassette, sub-family A (ABC1), member 7	ABCA7	Chr:19p13.3	NM_019112	Hs.134514	36	2.4	*
13	206289_at	homeo box A4	HOXA4	Chr:7p15-p14	NM_002141	Hs.147747	41	1.8
14	211926_s_at	myosin, heavy polypeptide 9, non-muscle	MYH9	Chr:22q13.1	AI827941	Hs.146550	48	2.6	*
15	200897_s_at	palladin	KIAA0992	Chr:4q32.3	NM_016081	Hs.194431	52	2.1
16	209822_s_at	very low density lipoprotein receptor	VLDLR	Chr:9p24	L22431	Hs.370422	57	6.1	*
17	208679_s_at	actin related protein 2/3 complex, subunit 2, 34kDa	ARPC2	Chr:2q36.1	AF279893	Hs.83583	67	1.6	*
18	212588_at	protein tyrosine phosphatase, receptor type, C	PTPRC	Chr:1q31-q32	Y00062	Hs.444324	69	1.5	*
19	201818_at	hypothetical protein FLJ12443	FLJ12443	Chr:5p15.33	NM_024830	Hs.179882	77	1.2
20	201705_at	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog)	PSMD7	Chr:16q23-q24	NM_002811	Hs.440604	92	1.0
21	207419_s_at	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	RAC2	Chr:22q13.1	NM_002872	Hs.301175	98	2.1	*

^aIndicated rankings correspond to those shown in Table S13. ^bFold change was calculated as the ratio of the mean signal in cases containing MLL chimeric fusion gene to mean signal of sorted normal bone marrow CD34+ cells (n=4). ^Can * marks genes with a fold change that was statistically significant at a level of p≤ 0.001 by a t-test.