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Supplementary Information

Gene Expression Profiling of Pediatric Acute Myelogenous Leukemia

Section III: Genetic Subtype Discriminating Genes

Table S9. Top 63 probe sets selected by SAM for inv(16) [CBFb-MYH11]

  U133 probe set Gene description Symbol Location GenBank reference UniGene reference SAM d-score Inv(16) Above/ Below mean Fold change
1 201497_x_at myosin, heavy polypeptide 11, smooth muscle MYH11 Chr:16p13.13-p13.12 NM_022844 Hs.78344 23.3 Above 12.9
2 205330_at meningioma (disrupted in balanced translocation) 1 MN1 Chr:22q11 NM_002430 Hs.268515 9.7 Above 4.6
3 200665_s_at secreted protein, acidic, cysteine-rich (osteonectin) SPARC Chr:5q31.3-q32 NM_003118 Hs.111779 7.4 Above 4.0
4 212298_at neuropilin 1 NRP1 Chr:10p12 BE620457 Hs.173548 7.3 Above 5.5
5 202370_s_at core-binding factor, beta subunit CBFB Chr:16q22.1 NM_001755 Hs.179881 -6.9 Below 2.5
6 219243_at immunity associated protein 4 HIMAP4 Chr:7q36.1 NM_018326 Hs.30822 6.8 Above 5.2
7 204661_at CDW52 antigen (CAMPATH-1 antigen) CDW52 Chr:1p36 NM_001803 Hs.276770 6.4 Above 3.4
8 34210_at CDW52 antigen (CAMPATH-1 antigen) CDW52 Chr:1p36 N90866 Hs.276770 6.4 Above 3.5
9 204912_at interleukin 10 receptor, alpha IL10RA Chr:11q23 NM_001558 Hs.327 6.3 Above 2.8
10 206978_at chemokine (C-C motif) receptor 2 CCR2 Chr:3p21 NM_000647 Hs.511794 6.3 Above 3.9
11 206135_at suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein) ST18 Chr:8q11.22 NM_014682 Hs.151449 6.2 Above 6.6
12 209395_at chitinase 3-like 1 (cartilage glycoprotein-39) CHI3L1 Chr:1q32.1 M80927 Hs.382202 6.2 Above 11.2
13 219308_s_at adenylate kinase 5 AK5 Chr:1p31 NM_012093 Hs.18268 6.1 Above 3.6
14 204588_s_at solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 SLC7A7 Chr:14q11.2 NM_003982 Hs.194693 5.9 Above 3.8
15 207794_at chemokine (C-C motif) receptor 2 CCR2 Chr:3p21 NM_000648 Hs.511794 5.7 Above 3.8
16 218454_at hypothetical protein FLJ22662 FLJ22662 Chr:12p13.2 NM_024829 Hs.178470 5.7 Above 5.7
17 203535_at S100 calcium binding protein A9 (calgranulin B) S100A9 Chr:1q21 NM_002965 Hs.112405 5.7 Above 3.9
18 218237_s_at solute carrier family 38, member 1 SLC38A1 Chr:12q13.11 NM_030674 Hs.132246 5.6 Above 2.6
19 202902_s_at cathepsin S CTSS Chr:1q21 NM_004079 Hs.181301 5.6 Above 3.2
20 205174_s_at glutaminyl-peptide cyclotransferase (glutaminyl cyclase) QPCT Chr:2p22.3 NM_012413 Hs.79033 5.6 Above 4.9
21 203329_at protein tyrosine phosphatase, receptor type, M PTPRM Chr:18p11.2 NM_002845 Hs.154151 5.5 Above 3.0
22 202901_x_at cathepsin S CTSS Chr:1q21 BC002642 Hs.181301 5.5 Above 2.7
23 212552_at hippocalcin-like 1 HPCAL1 Chr:2p25.1 BE617588 Hs.3618 5.4 Above 1.8
24 201496_x_at myosin, heavy polypeptide 11, smooth muscle MYH11 Chr:16p13.13-p13.12 S67238 Hs.78344 5.4 Above 4.9
25 204036_at endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 EDG2 Chr:9q32 AW269335 Hs.75794 5.3 Above 2.6
26 202944_at N-acetylgalactosaminidase, alpha- NAGA Chr:22q13-qter NM_000262 Hs.75372 5.3 Above 2.4
27 222144_at kinesin family member 17 KIF17 Chr:1p36.12 AA909345 Hs.130411 5.3 Above 3.8
28 209396_s_at chitinase 3-like 1 (cartilage glycoprotein-39) CHI3L1 Chr:1q32.1 M80927 Hs.382202 5.1 Above 5.3
29 212192_at hypothetical protein BC013764 LOC115207 Chr:13q22.1 AI718937 Hs.109438 5.0 Above 3.9
30 205987_at CD1C antigen, c polypeptide CD1C Chr:1q22-q23 NM_001765 Hs.1311 5.0 Above 3.8
31 202917_s_at S100 calcium binding protein A8 (calgranulin A) S100A8 Chr:1q21 NM_002964 Hs.416073 5.0 Above 2.8
32 208450_at lectin, galactoside-binding, soluble, 2 (galectin 2) LGALS2 Chr:22q12-q13 NM_006498 Hs.113987 5.0 Above 5.3
33 208890_s_at plexin B2 PLXNB2 Chr:22q13.33 BC004542 Hs.3989 4.9 Above 2.1
34 203923_s_at cytochrome b-245, beta polypeptide (chronic granulomatous disease) CYBB Chr:Xp21.1 NM_000397 Hs.88974 4.9 Above 2.7
35 212535_at MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A) MEF2A Chr:15q26 AA142929 Hs.415033 4.8 Above 1.6
36 215784_at CD1E antigen, e polypeptide CD1E Chr:1q22-q23 AA309511 Hs.249217 4.8 Above 4.6
37 205076_s_at cisplatin resistance associated CRA Chr:1q12-q21 NM_006697 Hs.425144 4.7 Above 3.1
38 202510_s_at tumor necrosis factor, alpha-induced protein 2 TNFAIP2 Chr:14q32 NM_006291 Hs.101382 4.7 Above 2.4
39 204037_at endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 EDG2 Chr:9q32 BF055366 Hs.75794 4.7 Above 2.6
40 212188_at hypothetical protein BC013764 LOC115207 Chr:13q22.1 AA551075 Hs.109438 4.7 Above 4.6
41 206682_at C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 13 (macrophage-derived) CLECSF13 Chr:17p13.2 NM_006344 Hs.54403 4.7 Above 3.9
42 216984_x_at immunoglobulin lambda joining 3 IGLJ3 Chr:22q11.1-q11.2 D84143 Hs.449592 4.6 Above 3.3
43 214684_at MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A) MEF2A Chr:15q26 X63381 Hs.415033 4.6 Above 1.7
44 221698_s_at C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12 CLECSF12 Chr:12p13.2-p12.3 AF313468 Hs.161786 4.6 Above 4.2
45 208891_at dual specificity phosphatase 6 DUSP6 Chr:12q22-q23 BC003143 Hs.298654 4.6 Above 2.3
46 206200_s_at annexin A11 ANXA11 Chr:10q23 NM_001157 Hs.75510 4.6 Above 1.5
47 201887_at interleukin 13 receptor, alpha 1 IL13RA1 Chr:Xq24 NM_001560 Hs.285115 4.6 Above 2.1
48 201968_s_at phosphoglucomutase 1 PGM1 Chr:1p31 NM_002633 Hs.1869 -4.5 Below 2.4
49 201999_s_at t-complex-associated-testis-expressed 1-like 1 TCTEL1 Chr:6q25.2-q25.3 NM_006519 Hs.266940 4.5 Above 1.5
50 206380_s_at properdin P factor, complement PFC Chr:Xp11.3-p11.23 NM_002621 Hs.53155 4.5 Above 3.0
51 212993_at hypothetical protein MGC23427 MGC23427 Chr:9q34.3 AA114166 Hs.244847 4.5 Above 2.7
52 211675_s_at I-mfa domain-containing protein HIC Chr:7q31.2 AF054589 Hs.132739 4.5 Above 2.0
53 201506_at transforming growth factor, beta-induced, 68kDa TGFBI Chr:5q31 NM_000358 Hs.421496 4.5 Above 4.9
54 211794_at FYN binding protein (FYB-120/130) FYB Chr:5p13.1 AF198052 Hs.276506 4.5 Above 3.1
55 221724_s_at C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6 CLECSF6 Chr:12p13 AF200738 Hs.115515 4.5 Above 3.9
56 206788_s_at core-binding factor, beta subunit CBFB Chr:16q22.1 AF294326 Hs.179881 -4.5 Below 2.2
57 203973_s_at KIAA0146 protein KIAA0146 Chr:8q11.21 NM_005195 Hs.381058 4.5 Above 2.0
58 214864_s_at glyoxylate reductase/hydroxypyruvate reductase GRHPR Chr:9q12 AK024386 Hs.155742 4.4 Above 1.5
59 212830_at EGF-like-domain, multiple 5 EGFL5 Chr:9q32-q33.3 W68084 Hs.236216 4.4 Above 2.2
60 211645_x_at Homo sapiens isolate donor Z clone Z55K immunoglobulin kappa light chain variable region mRNA, partial cds --- --- M85256 Hs.512133 4.4 Above 2.7
61 211798_x_at immunoglobulin lambda joining 3 IGLJ3 Chr:22q11.1-q11.2 AB001733 Hs.102950 4.4 Above 2.92
62 202720_at testis derived transcript (3 LIM domains) TES Chr:7q31.2 NM_015641 Hs.129129 4.4 Above 1.73
63 210314_x_at tumor necrosis factor (ligand) superfamily, member 13 TNFSF13 Chr:17p13.1 AF114013 Hs.54673 4.4 Above 2.22