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Supplementary Information

Gene Expression Profiling of Pediatric Acute Myelogenous Leukemia

Section III: Genetic Subtype Discriminating Genes

Table S8. Top 100 probe sets selected by SAM for t(15;17) [PML-RARa]

  U133 probe set Gene description Symbol Location GenBank reference UniGene reference SAM d-score t(15;17) Above/ Below mean Fold change
1 210755_at hepatocyte growth factor (hepapoietin A; scatter factor) HGF Chr:7q21.1 U46010 Hs.396530 20.1 Above 11.1
2 204150_at stabilin 1 STAB1 Chr:3p21.31 NM_015136 Hs.301989 19.7 Above 16.7
3 38487_at stabilin 1 STAB1 Chr:3p21.31 D87433 Hs.301989 18.8 Above 13.8
4 209960_at hepatocyte growth factor (hepapoietin A; scatter factor) HGF Chr:7q21.1 X16323 Hs.396530 16.7 Above 9.6
5 221804_s_at uncharacterized hypothalamus protein HT011 HT011 Chr:Xq26.1 BE565675 Hs.434241 16.0 Above 3.9
6 211748_x_at prostaglandin D2 synthase 21kDa (brain) PTGDS Chr:9q34.2-q34.3 BC005939 Hs.446429 15.4 Above 20.7
7 211663_x_at prostaglandin D2 synthase 21kDa (brain) PTGDS Chr:9q34.2-q34.3 M61900 Hs.446429 15.1 Above 13.4
8 210997_at hepatocyte growth factor (hepapoietin A; scatter factor) HGF Chr:7q21.1 M77227 Hs.396530 15.0 Above 17.8
9 218618_s_at FAD104 FAD104 Chr:3q26.31 NM_022763 Hs.299883 14.8 Above 4.5
10 212187_x_at prostaglandin D2 synthase 21kDa (brain) PTGDS Chr:9q34.2-q34.3 NM_000954 Hs.446429 14.6 Above 20.6
11 219225_at piggyBac transposable element derived 5 PGBD5 Chr:1q42.2 NM_024554 Hs.12247 14.3 Above 9.8
12 209961_s_at hepatocyte growth factor (hepapoietin A; scatter factor) HGF Chr:7q21.1 M60718 Hs.396530 14.2 Above 4.0
13 37408_at mannose receptor, C type 2 MRC2 Chr:17q24.1 AB014609 Hs.7835 14.1 Above 4.5
14 212285_s_at agrin AGRN Chr:1p36.33 AW008051 Hs.273330 13.9 Above 4.3
15 210998_s_at hepatocyte growth factor (hepapoietin A; scatter factor) HGF Chr:7q21.1 M77227 Hs.396530 13.9 Above 12.8
16 39248_at aquaporin 3 AQP3 Chr:9p13 N74607 Hs.234642 13.2 Above 6.0
17 201069_at matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) MMP2 Chr:16q13-q21 NM_004530 Hs.367877 12.9 Above 8.3
18 217419_x_at agrin AGRN Chr:1p36.33 AK021586 Hs.273330 12.8 Above 3.4
19 210140_at cystatin F (leukocystatin) CST7 Chr:20p11.21 AF031824 Hs.143212 11.8 Above 6.7
20 214228_x_at tumor necrosis factor receptor superfamily, member 4 TNFRSF4 Chr:1p36 AJ277151 Hs.129780 11.6 Above 10.6
21 201063_at reticulocalbin 1, EF-hand calcium binding domain RCN1 Chr:11p13 NM_002901 Hs.167791 11.2 Above 2.8
22 203074_at annexin A8 ANXA8 Chr:10q11.2 NM_001630 Hs.87268 11.2 Above 6.3
23 212953_x_at calreticulin CALR Chr:19p13.3-p13.2 BE251303 Hs.353170 11.1 Above 3.1
24 216320_x_at macrophage stimulating 1 (hepatocyte growth factor-like) MST1 Chr:3p21 U37055 Hs.512587 11.0 Above 5.6
25 205614_x_at macrophage stimulating 1 (hepatocyte growth factor-like) MST1 Chr:3p21 NM_020998 Hs.512587 10.9 Above 7.2
26 214315_x_at calreticulin CALR Chr:19p13.3-p13.2 AI348935 Hs.353170 10.8 Above 2.6
27 205110_s_at fibroblast growth factor 13 FGF13 Chr:Xq26.3 NM_004114 Hs.6540 10.6 Above 10.5
28 221971_x_at Homo sapiens similar to ARF GTPase-activating protein (LOC283018), mRNA --- --- BE672818 Hs.448612 10.3 Above 3.1
29 212509_s_at Homo sapiens transcribed sequence with strong similarity to protein sp:P05023 (H.sapiens) A1A1_HUMAN Sodium/potassium-transporting ATPase alpha-1 chain precursor (Sodium pump 1) (Na+/K+ ATPase 1) --- --- BF968134 Hs.356623 10.2 Above 3.7
30 213492_at collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) COL2A1 Chr:12q13.11-q13.2 X06268 Hs.408182 10.1 Above 4.3
31 202260_s_at syntaxin binding protein 1 STXBP1 Chr:9q34.1 NM_003165 Hs.325862 10.1 Above 4.1
32 205899_at cyclin A1 CCNA1 Chr:13q12.3-q13 NM_003914 Hs.417050 10.0 Above 7.2
33 213380_x_at macrophage stimulating, pseudogene 9 MSTP9 Chr:1p36.13 AA911235 Hs.475654 9.9 Above 2.9
34 202718_at insulin-like growth factor binding protein 2, 36kDa IGFBP2 Chr:2q33-q34 NM_000597 Hs.433326 9.8 Above 7.0
35 45687_at hypothetical protein MGC3121 MGC3121 Chr:16p11.2 AA161130 Hs.293629 9.8 Above 2.1
36 214450_at cathepsin W (lymphopain) CTSW Chr:11q13.1 NM_001335 Hs.416848 9.8 Above 4.8
37 218922_s_at hypothetical protein FLJ12089 FLJ12089 Chr:19p13.3 NM_024552 Hs.300439 9.6 Above 5.3
38 219527_at hypothetical protein FLJ20605 FLJ20605 Chr:1q42.11 NM_017898 Hs.4932 9.6 Above 4.0
39 221850_x_at Homo sapiens cDNA FLJ38788 fis, clone LIVER2002638. --- --- AI826075 Hs.446716 9.4 Above 2.6
40 218714_at hypothetical protein MGC3121 MGC3121 Chr:16p11.2 NM_024031 Hs.293629 9.4 Above 2.3
41 216614_at --- --- --- AL049988 --- 9.3 Above 4.7
42 201591_s_at nischarin NISCH Chr:3p21.1 NM_007184 Hs.435290 9.3 Above 2.1
43 204425_at Rho GTPase activating protein 4 ARHGAP4 Chr:Xq28 NM_001666 Hs.3109 -9.3 Below 17.6
44 212599_at autism susceptibility candidate 2 AUTS2 Chr:7q11.23 AK025298 Hs.296720 9.3 Above 3.0
45 203916_at N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 NDST2 Chr:10q22 NM_003635 Hs.225129 9.3 Above 2.3
46 205624_at carboxypeptidase A3 (mast cell) CPA3 Chr:3q21-q25 NM_001870 Hs.646 9.2 Above 6.0
47 207895_at N-acetylated alpha-linked acidic dipeptidase-like NAALADASEL Chr:11q12 NM_005468 Hs.13967 9.2 Above 8.6
48 203151_at microtubule-associated protein 1A MAP1A Chr:15q13-qter AW296788 Hs.194301 9.1 Above 2.9
49 203949_at myeloperoxidase MPO Chr:17q23.1 NM_000250 Hs.458272 9.1 Above 3.7
50 201952_at activated leukocyte cell adhesion molecule ALCAM Chr:3q13.1 AA156721 Hs.10247 9.1 Above 3.0
51 209574_s_at chromosome 18 open reading frame 1 C18orf1 Chr:18p11.2 AI349506 Hs.285091 9.0 Above 3.2
52 212012_at Melanoma associated gene D2S448 Chr:2pter-p25.1 BF342851 Hs.118893 9.0 Above 5.7
53 207106_s_at leukocyte tyrosine kinase LTK Chr:15q15.1-q21.1 NM_002344 Hs.434481 9.0 Above 4.1
54 202655_at arginine-rich, mutated in early stage tumors ARMET Chr:3p21.1 NM_006010 Hs.436446 9.0 Above 2.2
55 219491_at hypothetical protein MGC3103 MGC3103 Chr:11q13.1 NM_024036 Hs.148438 9.0 Above 3.8
56 212204_at DKFZP564G2022 protein DKFZP564G2022 Chr:15q14 AL049944 Hs.200692 9.0 Above 1.9
57 212013_at Melanoma associated gene D2S448 Chr:2pter-p25.1 D86983 Hs.118893 8.9 Above 7.5
58 216268_s_at jagged 1 (Alagille syndrome) JAG1 Chr:20p12.1-p11.23 U77914 Hs.409202 8.8 Above 5.0
59 213355_at alpha2,3-sialyltransferase ST3GALVI Chr:3q12.2 AI989567 Hs.440913 8.8 Above 3.2
60 203221_at transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) TLE1 Chr:9q21.32 AI758763 Hs.406491 8.7 Above 3.5
61 217653_x_at Homo sapiens transcribed sequence with weak  similarity to protein ref:NP_060312.1 (H.sapiens)  hypothetical protein FLJ20489 [Homo sapiens] --- --- AW150065 Hs.499531 8.7 Above 2.9
62 214203_s_at proline dehydrogenase (oxidase) 1 PRODH Chr:22q11.21 AA074145 Hs.343874 8.6 Above 5.1
63 221799_at KIAA1402 protein CSGlcA-T Chr:7q36.1 AB037823 Hs.86392 8.6 Above 2.3
64 212810_s_at solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 SLC1A4 Chr:2p15-p13 W72527 Hs.323878 8.6 Above 2.5
65 200986_at serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) SERPING1 Chr:11q12-q13.1 NM_000062 Hs.384598 8.5 Above 4.5
66 201596_x_at keratin 18 KRT18 Chr:12q13 NM_000224 Hs.406013 8.5 Above 4.0
67 221636_s_at hypothetical protein FLJ20605 FLJ20605 Chr:1q42.11 AL136931 Hs.4932 8.5 Above 3.2
68 205047_s_at asparagine synthetase ASNS Chr:7q21.3 NM_001673 Hs.446546 8.4 Above 3.6
69 200654_at procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase; thyroid hormone binding protein p55) P4HB Chr:17q25 J02783 Hs.410578 8.3 Above 2.4
70 203364_s_at KIAA0652 gene product KIAA0652 Chr:11p11.2 NM_014741 Hs.410092 8.3 Above 1.7
71 219167_at Ras family member Ris RIS Chr:15q11.2-q22.33 NM_016563 Hs.27018 8.3 Above 4.5
72 214582_at phosphodiesterase 3B, cGMP-inhibited PDE3B Chr:11p15.1 NM_000753 Hs.337616 8.3 Above 2.2
73 204446_s_at arachidonate 5-lipoxygenase ALOX5 Chr:10q11.2 NM_000698 Hs.89499 8.2 Above 4.1
74 200935_at calreticulin CALR Chr:19p13.3-p13.2 NM_004343 Hs.353170 8.2 Above 3.6
75 210794_s_at maternally expressed 3 MEG3 Chr:14q32 AF119863 Hs.418271 8.2 Above 26.0
76 203948_s_at myeloperoxidase MPO Chr:17q23.1 J02694 Hs.458272 8.1 Above 3.3
77 213942_at EGF-like-domain, multiple 3 EGFL3 Chr:1p36.3 AL134303 Hs.56186 8.1 Above 2.7
78 200945_s_at yeast Sec31p homolog KIAA0905 Chr:4q21.3 NM_014933 Hs.436549 8.1 Above 1.5
79 204099_at SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 SMARCD3 Chr:7q35-q36 NM_003078 Hs.444445 8.0 Above 3.2
80 206335_at galactosamine (N-acetyl)-6-sulfate sulfatase (Morquio syndrome, mucopolysaccharidosis type IVA) GALNS Chr:16q24.3 NM_000512 Hs.159479 8.0 Above 2.1
81 209686_at S100 calcium binding protein, beta (neural) S100B Chr:21q22.3 BC001766 Hs.422181 8.0 Above 10.0
82 217961_at hypothetical protein FLJ20551 FLJ20551 Chr:3p21.33 NM_017875 Hs.7994 7.9 Above 1.8
83 202650_s_at KIAA0195 gene product KIAA0195 Chr:17q25.3 NM_014738 Hs.301132 7.9 Above 2.1
84 206105_at fragile X mental retardation 2 FMR2 Chr:Xq28 NM_002025 Hs.54472 7.9 Above 2.4
85 205382_s_at D component of complement (adipsin) DF Chr:19p13.3 NM_001928 Hs.155597 7.9 Above 3.5
86 202956_at brefeldin A-inhibited guanine nucleotide-exchange protein 1 BIG1 Chr:8q13 NM_006421 Hs.94631 7.9 Above 1.9
87 205518_s_at Homo sapiens mRNA for CMP-N-acetylneuraminic acid hydroxylase, complete cds. --- --- NM_003570 Hs.24697 7.8 Above 2.6
88 219868_s_at ankyrin repeat and FYVE domain containing 1 ANKFY1 Chr:17p13.3 NM_016376 Hs.512604 7.8 Above 1.9
89 209099_x_at jagged 1 (Alagille syndrome) JAG1 Chr:20p12.1-p11.23 U73936 Hs.409202 7.8 Above 4.3
90 212566_at microtubule-associated protein 4 MAP4 Chr:3p21 AL523310 Hs.31095 7.8 Above 1.6
91 211936_at heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) HSPA5 Chr:9q33-q34.1 AF216292 Hs.310769 7.7 Above 2.6
92 202660_at Homo sapiens transcribed sequences --- --- AA834576 Hs.406751 7.6 Above 2.9
93 213348_at cyclin-dependent kinase inhibitor 1C (p57, Kip2) CDKN1C Chr:11p15.5 N33167 Hs.106070 7.6 Above 2.7
94 221042_s_at calmin (calponin-like, transmembrane) CLMN Chr:14q32.2 NM_024734 Hs.301478 7.6 Above 3.8
95 213385_at chimerin (chimaerin) 2 CHN2 Chr:7p15.3 AK026415 Hs.407520 7.6 Above 3.0
96 202662_s_at inositol 1,4,5-triphosphate receptor, type 2 ITPR2 Chr:12p11 NM_002223 Hs.512235 7.6 Above 2.5
97 200825_s_at hypoxia up-regulated 1 HYOU1 Chr:11q23.1-q23.3 NM_006389 Hs.277704 7.6 Above 2.0
98 205505_at glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase) GCNT1 Chr:9q13 NM_001490 Hs.159642 7.6 Above 2.3
99 210999_s_at growth factor receptor-bound protein 10 GRB10 Chr:7p12-p11.2 U66065 Hs.512118 7.6 Above 2.9
100 201581_at hypothetical protein DJ971N18.2 DJ971N18.2 Chr:20p12 BF572868 Hs.169358 7.5 Above 2.0