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Supplementary Information

Gene Expression Profiling of Pediatric Acute Myelogenous Leukemia

Section III: Genetic Subtype Discriminating Genes

Table S11. Top 100 Probe sets selected by SAM for FAB-M7

  U133 probe set Gene description Symbol Location GenBank reference UniGene reference SAM d-score M7 Above/ Below mean Fold change
1 206493_at integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) ITGA2B Chr:17q21.32 NM_000419 Hs.411312 24.4 Above 26.1
2 206494_s_at integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) ITGA2B Chr:17q21.32 NM_000419 Hs.411312 23.9 Above 35.8
3 216956_s_at integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) ITGA2B Chr:17q21.32 AF098114 Hs.411312 19.5 Above 53.0
4 201147_s_at tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory) TIMP3 Chr:22q12.1-q13.2 BF347089 Hs.245188 16.6 Above 23.8
5 210762_s_at deleted in liver cancer 1 DLC1 Chr:8p22 AF026219 Hs.8700 16.1 Above 8.4
6 221896_s_at likely ortholog of mouse hypoxia induced gene 1 HIG1 Chr:3p21.33 BE739519 Hs.7917 16.0 Above 5.2
7 217845_x_at likely ortholog of mouse hypoxia induced gene 1 HIG1 Chr:3p21.33 NM_014056 Hs.7917 16.0 Above 3.9
8 206655_s_at glycoprotein Ib (platelet), beta polypeptide GP1BB Chr:22q11.21-q11.23 NM_000407 Hs.512000 15.5 Above 21.7
9 206283_s_at T-cell acute lymphocytic leukemia 1 TAL1 Chr:1p32 NM_003189 Hs.73828 14.3 Above 7.8
10 209839_at KIAA0820 protein KIAA0820 Chr:1q24.1 AL136712 Hs.327347 13.8 Above 6.8
11 201150_s_at tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory) TIMP3 Chr:22q12.1-q13.2 NM_000362 Hs.245188 13.3 Above 13.2
12 210446_at GATA binding protein 1 (globin transcription factor 1) GATA1 Chr:Xp11.23 M30601 Hs.765 13.3 Above 7.2
13 205352_at serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1 SERPINI1 Chr:3q26.2 NM_005025 Hs.78589 12.8 Above 13.6
14 208971_at uroporphyrinogen decarboxylase UROD Chr:1p34 M14016 Hs.78601 12.5 Above 3.2
15 206145_at Rhesus blood group-associated glycoprotein RHAG Chr:6p21.1-p11 NM_000324 Hs.368178 12.4 Above 20.3
16 208767_s_at lysosomal associated protein transmembrane 4 beta LAPTM4B Chr:8q22.1 AW149681 Hs.296398 12.3 Above 8.0
17 208970_s_at uroporphyrinogen decarboxylase UROD Chr:1p34 M14016 Hs.78601 12.3 Above 3.7
18 214039_s_at lysosomal associated protein transmembrane 4 beta LAPTM4B Chr:8q22.1 T15777 Hs.296398 12.0 Above 9.7
19 212372_at myosin, heavy polypeptide 10, non-muscle MYH10 Chr:17p13 AK026977 Hs.280311 12.0 Above 8.1
20 213107_at Traf2 and NCK interacting kinase KIAA0551 Chr:3q26.31 R59093 Hs.252550 11.5 Above 5.0
21 216054_x_at myosin, light polypeptide 4, alkali; atrial, embryonic MYL4 Chr:17q21-qter X58851 Hs.356717 11.5 Above 6.2
22 211254_x_at Rhesus blood group-associated glycoprotein RHAG Chr:6p21.1-p11 AF031549 Hs.368178 11.4 Above 8.1
23 212412_at LIM protein (similar to rat protein kinase C-binding enigma) LIM Chr:4q22 AV715767 Hs.154103 11.4 Above 6.8
24 221021_s_at catenin, beta like 1 CTNNBL1 Chr:20q11.23-q12 NM_030877 Hs.178576 11.2 Above 3.3
25 210395_x_at myosin, light polypeptide 4, alkali; atrial, embryonic MYL4 Chr:17q21-qter AF116676 Hs.356717 11.2 Above 6.0
26 205390_s_at ankyrin 1, erythrocytic ANK1 Chr:8p11.1 NM_000037 Hs.443711 11.2 Above 15.0
27 212694_s_at propionyl Coenzyme A carboxylase, beta polypeptide PCCB Chr:3q21-q22 NM_000532 Hs.63788 11.1 Above 2.8
28 208029_s_at lysosomal associated protein transmembrane 4 beta LAPTM4B Chr:8q22.1 NM_018407 Hs.296398 11.0 Above 12.1
29 218711_s_at serum deprivation response (phosphatidylserine binding protein) SDPR Chr:2q32-q33 NM_004657 Hs.26530 10.9 Above 6.7
30 210088_x_at myosin, light polypeptide 4, alkali; atrial, embryonic MYL4 Chr:17q21-qter M36172 Hs.356717 10.7 Above 5.7
31 219546_at BMP2 inducible kinase BMP2K Chr:4q21.23 NM_017593 Hs.20137 10.6 Above 4.6
32 206146_s_at Rhesus blood group-associated glycoprotein RHAG Chr:6p21.1-p11 AF178841 Hs.368178 10.6 Above 28.7
33 209585_s_at multiple inositol polyphosphate histidine phosphatase, 1 MINPP1 Chr:10q23 AF084943 Hs.95907 10.5 Above 4.8
34 207808_s_at protein S (alpha) PROS1 Chr:3p11-q11.2 NM_000313 Hs.64016 10.4 Above 9.1
35 211828_s_at Traf2 and NCK interacting kinase KIAA0551 Chr:3q26.31 AF172268 Hs.252550 10.4 Above 7.1
36 204720_s_at DnaJ (Hsp40) homolog, subfamily C, member 6 DNAJC6 Chr:1pter-q31.3 AV729634 Hs.44896 10.3 Above 10.0
37 204416_x_at apolipoprotein C-I APOC1 Chr:19q13.2 NM_001645 Hs.268571 10.3 Above 31.3
38 210215_at transferrin receptor 2 TFR2 Chr:7q22 AF067864 Hs.63758 10.3 Above 17.2
39 205128_x_at prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) PTGS1 Chr:9q32-q33.3 NM_000962 Hs.88474 10.2 Above 3.7
40 203382_s_at apolipoprotein E APOE Chr:19q13.2 NM_000041 Hs.110675 10.2 Above 16.2
41 209881_s_at linker for activation of T cells LAT Chr:16p12.1 AF036905 Hs.498997 10.2 Above 10.1
42 210504_at Kruppel-like factor 1 (erythroid) KLF1 Chr:19p13.13-p13.12 U65404 Hs.37860 10.0 Above 5.4
43 201830_s_at neuroepithelial cell transforming gene 1 NET1 Chr:10p15 NM_005863 Hs.25155 10.0 Above 5.1
44 207194_s_at intercellular adhesion molecule 4, Landsteiner-Wiener blood group ICAM4 Chr:19p13.2-cen NM_001544 Hs.512159 9.9 Above 4.5
45 202753_at proteasome regulatory particle subunit p44S10 p44S10 Chr:3p21.1 NM_014814 Hs.350939 9.8 Above 1.8
46 205127_at prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) PTGS1 Chr:9q32-q33.3 NM_000962 Hs.88474 9.8 Above 6.6
47 203243_s_at LIM protein (similar to rat protein kinase C-binding enigma) LIM Chr:4q22 NM_006457 Hs.154103 9.7 Above 5.6
48 210986_s_at tropomyosin 1 (alpha) TPM1 Chr:15q22.1 Z24727 Hs.133892 9.6 Above 6.0
49 210987_x_at --- --- --- M19267 --- 9.6 Above 3.5
50 200642_at superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) SOD1 Chr:21q22.1 NM_000454 Hs.443914 9.6 Above 2.6
51 209586_s_at TcD37 homolog HTCD37 Chr:1q21 AF123539 Hs.78524 9.6 Above 2.5
52 215813_s_at prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) PTGS1 Chr:9q32-q33.3 S36219 Hs.88474 9.5 Above 3.6
53 217963_s_at nerve growth factor receptor (TNFRSF16) associated protein 1 NGFRAP1 Chr:Xq22.2 NM_014380 Hs.448588 9.4 Above 7.4
54 218111_s_at cytidine monophosphate N-acetylneuraminic acid synthetase CMAS Chr:12p12.2 NM_018686 Hs.311346 9.3 Above 2.7
55 210036_s_at potassium voltage-gated channel, subfamily H (eag-related), member 2 KCNH2 Chr:7q35-q36 AB044806 Hs.188021 9.3 Above 6.5
56 204331_s_at mitochondrial ribosomal protein S12 MRPS12 Chr:19q13.1-q13.2 NM_021107 Hs.411125 9.3 Above 3.1
57 207389_at glycoprotein Ib (platelet), alpha polypeptide GP1BA Chr:17pter-p12 NM_000173 Hs.1472 9.3 Above 6.6
58 205262_at potassium voltage-gated channel, subfamily H (eag-related), member 2 KCNH2 Chr:7q35-q36 NM_000238 Hs.188021 9.3 Above 21.6
59 202218_s_at fatty acid desaturase 2 FADS2 Chr:11q12-q13.1 NM_004265 Hs.388164 9.3 Above 3.7
60 203196_at ATP-binding cassette, sub-family C (CFTR/MRP), member 4 ABCC4 Chr:13q32 AI948503 Hs.307915 9.2 Above 5.4
61 206077_at Kell blood group KEL Chr:7q33 NM_000420 Hs.420322 9.1 Above 6.4
62 213553_x_at apolipoprotein C-I APOC1 Chr:19q13.2 W79394 Hs.268571 9.1 Above 5.9
63 211005_at linker for activation of T cells LAT Chr:16p12.1 AF036906 Hs.498997 9.1 Above 6.7
64 204321_at neogenin homolog 1 (chicken) NEO1 Chr:15q22.3-q23 NM_002499 Hs.388613 9.0 Above 7.8
65 59644_at BMP2 inducible kinase BMP2K Chr:4q21.23 AI735391 Hs.20137 8.9 Above 3.4
66 210907_s_at programmed cell death 10 PDCD10 Chr:3q26.2 BC002506 Hs.424619 8.9 Above 1.9
67 203242_s_at LIM protein (similar to rat protein kinase C-binding enigma) LIM Chr:4q22 BG054550 Hs.154103 8.9 Above 5.7
68 212224_at aldehyde dehydrogenase 1 family, member A1 ALDH1A1 Chr:9q21.13 NM_000689 Hs.76392 8.8 Above 26.8
69 206306_at ryanodine receptor 3 RYR3 Chr:15q14-q15 NM_001036 Hs.427717 8.8 Above 11.6
70 216804_s_at LIM protein (similar to rat protein kinase C-binding enigma) LIM Chr:4q22 AK027217 Hs.154103 8.8 Above 10.2
71 209218_at squalene epoxidase SQLE Chr:8q24.1 AF098865 Hs.71465 8.8 Above 2.7
72 201148_s_at tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory) TIMP3 Chr:22q12.1-q13.2 AW338933 Hs.245188 8.8 Above 5.6
73 219215_s_at solute carrier family 39 (zinc transporter), member 4 SLC39A4 Chr:8q24.3 NM_017767 Hs.411274 8.8 Above 3.4
74 201149_s_at tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory) TIMP3 Chr:22q12.1-q13.2 U67195 Hs.245188 8.7 Above 3.0
75 202279_at chromosome 14 open reading frame 2 C14orf2 Chr:14q32.33 NM_004894 Hs.109052 8.7 Above 2.0
76 202949_s_at four and a half LIM domains 2 FHL2 Chr:2q12-q14 NM_001450 Hs.8302 8.6 Above 13.8
77 204904_at gap junction protein, alpha 4, 37kDa (connexin 37) GJA4 Chr:1p35.1 NM_002060 Hs.296310 8.6 Above 15.7
78 209710_at GATA binding protein 2 GATA2 Chr:3q21.3 AL563460 Hs.367725 8.5 Above 4.7
79 212397_at radixin RDX Chr:11q23 AL137751 Hs.263671 8.5 Above 2.8
80 205389_s_at ankyrin 1, erythrocytic ANK1 Chr:8p11.1 AI659683 Hs.443711 8.5 Above 4.8
81 210621_s_at RAS p21 protein activator (GTPase activating protein) 1 RASA1 Chr:5q13.3 M23612 Hs.758 8.4 Above 2.1
82 220994_s_at syntaxin binding protein 6 (amisyn) STXBP6 Chr:14q11.2 NM_014178 Hs.99291 8.4 Above 29.9
83 202620_s_at procollagen-lysine, 2-oxoglutarate 5-dioxygenase (lysine hydroxylase) 2 PLOD2 Chr:3q23-q24 NM_000935 Hs.41270 8.4 Above 10.1
84 203258_at DR1-associated protein 1 (negative cofactor 2 alpha) DRAP1 Chr:11q13.3 NM_006442 Hs.356742 8.4 Above 2.2
85 206702_at TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal) TEK Chr:9p21 NM_000459 Hs.89640 8.3 Above 10.6
86 206793_at phenylethanolamine N-methyltransferase PNMT Chr:17q21-q22 NM_002686 Hs.1892 8.3 Above 9.2
87 209049_s_at protein kinase C binding protein 1 PRKCBP1 Chr:20q13.13 BC001004 Hs.191990 8.3 Above 2.5
88 210532_s_at chromosome 14 open reading frame 2 C14orf2 Chr:14q32.33 AF116639 Hs.109052 8.3 Above 1.9
89 203486_s_at HSPC056 protein HSPC056 Chr:3q22.3 BF195973 Hs.102708 8.2 Above 3.3
90 202983_at SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3 SMARCA3 Chr:3q25.1-q26.1 AI760760 Hs.3068 8.2 Above 2.8
91 221488_s_at chromosome 6 open reading frame 82 C6orf82 Chr:6pter-p21.31 AF230924 Hs.107187 8.1 Above 1.7
92 213088_s_at DnaJ (Hsp40) homolog, subfamily C, member 9 DNAJC9 Chr:10q22.3 BE551340 Hs.400676 8.1 Above 2.2
93 216925_s_at T-cell acute lymphocytic leukemia 1 TAL1 Chr:1p32 X51990 Hs.73828 8.1 Above 4.5
94 208353_x_at ankyrin 1, erythrocytic ANK1 Chr:8p11.1 NM_020480 Hs.443711 8.0 Above 4.9
95 208352_x_at ankyrin 1, erythrocytic ANK1 Chr:8p11.1 NM_020479 Hs.443711 7.9 Above 4.9
96 221704_s_at hypothetical protein FLJ12750 FLJ12750 Chr:12q24.31 BC005882 Hs.77870 7.9 Above 3.0
97 208653_s_at CD164 antigen, sialomucin CD164 Chr:6q21 AF263279 Hs.43910 7.9 Above 3.1
98 203613_s_at NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa NDUFB6 Chr:9p13.3 NM_002493 Hs.109646 7.9 Above 2.0
99 219737_s_at Homo sapiens transcribed sequence with strong similarity to protein ref:NP_065136.1 (H.sapiens)  protocadherin 9 precursor; cadherin superfamily protein VR4-11 [Homo sapiens] --- --- AI524125 Hs.458282 7.9 Above 6.8
100 40687_at gap junction protein, alpha 4, 37kDa (connexin 37) GJA4 Chr:1p35.1 M96789 Hs.296310 7.8 Above 17.8