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Supplementary Information

Gene Expression Profiling of Pediatric Acute Myelogenous Leukemia

Section III: Genetic Subtype Discriminating Genes

Table S10. Top 100 probe sets selected by SAM for MLL chimeric fusion genes

  U133 probe set Gene description Symbol Location GenBank reference UniGene reference SAM d-score MLL Above/ Below mean Fold change
1 205471_s_at dachshund homolog (Drosophila) DACH Chr:13q22 AW772082 Hs.63931 14.8 Above 11.9
2 205472_s_at dachshund homolog (Drosophila) DACH Chr:13q22 NM_004392 Hs.63931 13.9 Above 13.7
3 218376_s_at NEDD9 interacting protein with calponin homology and LIM domains NICAL Chr:6q21 NM_022765 Hs.33476 11.6 Above 3.0
4 204082_at pre-B-cell leukemia transcription factor 3 PBX3 Chr:9q33-q34 NM_006195 Hs.294101 11.3 Above 4.5
5 202053_s_at aldehyde dehydrogenase 3 family, member A2 ALDH3A2 Chr:17p11.2 L47162 Hs.440662 10.6 Above 2.4
6 212174_at adenylate kinase 2 AK2 Chr:1p34 W02312 Hs.294008 10.4 Above 2.5
7 212173_at adenylate kinase 2 AK2 Chr:1p34 AU154985 Hs.294008 9.7 Above 2.7
8 209616_s_at carboxylesterase 1 (monocyte/macrophage serine esterase 1) CES1 Chr:16q13-q22.1 S73751 Hs.278997 9.2 Above 22.3
9 201858_s_at proteoglycan 1, secretory granule PRG1 Chr:10q22.1 J03223 Hs.1908 9.2 Above 2.7
10 208967_s_at adenylate kinase 2 AK2 Chr:1p34 U39945 Hs.294008 9.1 Above 2.3
11 201850_at capping protein (actin filament), gelsolin-like CAPG Chr:2cen-q24 NM_001747 Hs.82422 9.0 Above 3.7
12 212175_s_at adenylate kinase 2 AK2 Chr:1p34 AL513611 Hs.294008 9.0 Above 2.2
13 204655_at chemokine (C-C motif) ligand 5 CCL5 Chr:17q11.2-q12 NM_002985 Hs.489044 8.4 Above 5.4
14 205996_s_at adenylate kinase 2 AK2 Chr:1p34 NM_013411 Hs.294008 8.3 Above 2.3
15 203372_s_at suppressor of cytokine signaling 2 SOCS2 Chr:12q AB004903 Hs.405946 8.3 Above 4.3
16 206111_at ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) RNASE2 Chr:14q24-q31 NM_002934 Hs.728 8.3 Above 3.8
17 206851_at ribonuclease, RNase A family, 3 (eosinophil cationic protein) RNASE3 Chr:14q24-q31 NM_002935 Hs.73839 8.2 Above 8.0
18 1405_i_at chemokine (C-C motif) ligand 5 CCL5 Chr:17q11.2-q12 M21121 Hs.489044 8.2 Above 6.9
19 216950_s_at Fc fragment of IgG, high affinity Ia, receptor for (CD64) FCGR1A Chr:1q21.2-q21.3 X14355 Hs.77424 8.2 Above 3.4
20 218217_at likely homolog of rat and mouse retinoid-inducible serine carboxypeptidase RISC Chr:17q23.2 NM_021626 Hs.431107 8.2 Above 3.8
21 209199_s_at MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) MEF2C Chr:5q14 N22468 Hs.368950 8.2 Above 2.7
22 203373_at suppressor of cytokine signaling 2 SOCS2 Chr:12q NM_003877 Hs.405946 8.1 Above 4.1
23 213915_at natural killer cell group 7 sequence NKG7 Chr:19q13.41 NM_005601 Hs.10306 8.1 Above 2.9
24 214511_x_at Fc fragment of IgG, high affinity Ia, receptor for (CD64) FCGR1A Chr:1q21.2-q21.3 L03419 Hs.77424 8.0 Above 3.6
25 208270_s_at arginyl aminopeptidase (aminopeptidase B) RNPEP Chr:1q32 NM_020216 Hs.283667 8.0 Above 2.1
26 200782_at annexin A5 ANXA5 Chr:4q26-q28 NM_001154 Hs.145741 7.9 Above 3.6
27 204674_at lymphoid-restricted membrane protein LRMP Chr:12p12.1 NM_006152 Hs.124922 7.9 Above 2.4
28 219360_s_at transient receptor potential cation channel, subfamily M, member 4 TRPM4 Chr:19q13.33 NM_017636 Hs.31608 7.7 Above 9.0
29 201003_x_at ubiquitin-conjugating enzyme E2 variant 1 UBE2V1 Chr:20q13.2 NM_003349 Hs.381025 7.7 Above 2.0
30 201944_at hexosaminidase B (beta polypeptide) HEXB Chr:5q13 NM_000521 Hs.69293 7.7 Above 2.5
31 202054_s_at aldehyde dehydrogenase 3 family, member A2 ALDH3A2 Chr:17p11.2 NM_000382 Hs.440662 7.7 Above 2.8
32 201050_at phospholipase D3 PLD3 Chr:19q13.2 NM_012268 Hs.257008 7.6 Above 8.0
33 209696_at fructose-1,6-bisphosphatase 1 FBP1 Chr:9q22.3 D26054 Hs.360509 7.5 Above 3.4
34 202139_at aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) AKR7A2 Chr:1p35.1-p36.23 NM_003689 Hs.512807 7.4 Above 2.3
35 204633_s_at ribosomal protein S6 kinase, 90kDa, polypeptide 5 RPS6KA5 Chr:14q31-q32.1 AF074393 Hs.109058 7.4 Above 2.3
36 216331_at integrin, alpha 7 ITGA7 Chr:12q13 AK022548 Hs.74369 7.4 Above 9.1
37 217861_s_at prolactin regulatory element binding PREB Chr:2p23.3 NM_013388 Hs.279784 7.3 Above 1.6
38 206050_s_at ribonuclease/angiogenin inhibitor RNH Chr:11p15.5 NM_002939 Hs.130958 7.2 Above 2.2
39 209663_s_at integrin, alpha 7 ITGA7 Chr:12q13 AF072132 Hs.74369 7.2 Above 5.6
40 35974_at lymphoid-restricted membrane protein LRMP Chr:12p12.1 U10485 Hs.124922 7.2 Above 2.8
41 204497_at adenylate cyclase 9 ADCY9 Chr:16p13.3 AB011092 Hs.20196 7.2 Above 6.5
42 209439_s_at phosphorylase kinase, alpha 2 (liver) PHKA2 Chr:Xp22.2-p22.1 D38616 Hs.54941 7.1 Above 1.9
43 205613_at B/K protein LOC51760 Chr:16p13.11 NM_016524 Hs.258326 7.1 Above 4.5
44 218109_s_at hypothetical protein FLJ14153 FLJ14153 Chr:3q25.32 NM_022736 Hs.7503 7.1 Above 1.6
45 210548_at chemokine (C-C motif) ligand 23 CCL23 Chr:17q21.1 U58913 Hs.169191 7.1 Above 10.2
46 205418_at feline sarcoma oncogene FES Chr:15q26.1 NM_002005 Hs.7636 7.0 Above 2.0
47 210549_s_at chemokine (C-C motif) ligand 23 CCL23 Chr:17q21.1 U58913 Hs.169191 7.0 Above 20.1
48 212080_at myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) MLL Chr:11q23 AV714029 Hs.258855 -7.0 Below 2.3
49 203052_at complement component 2 C2 Chr:6p21.3 NM_000063 Hs.2253 7.0 Above 4.0
50 206100_at carboxypeptidase M CPM Chr:12q15 NM_001874 Hs.511820 7.0 Above 3.9
51 213737_x_at Homo sapiens transcribed sequences --- --- AI620911 Hs.50787 7.0 Above 2.3
52 211067_s_at growth arrest-specific 7 GAS7 Chr:17p BC006454 Hs.226133 6.9 Above 2.2
53 207968_s_at MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) MEF2C Chr:5q14 NM_002397 Hs.368950 6.9 Above 2.2
54 200742_s_at ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease) CLN2 Chr:11p15 BG231932 Hs.429658 6.9 Above 1.9
55 217520_x_at similar to HP95 na Chr:15q12 BG396614 Hs.374397 6.8 Above 3.8
56 203781_at mitochondrial ribosomal protein L33 MRPL33 Chr:2p21 NM_004891 Hs.14454 6.8 Above 2.7
57 204561_x_at apolipoprotein C-II APOC2 Chr:19q13.2 NM_000483 Hs.75615 6.8 Above 10.7
58 218176_at melanoma antigen, family F, 1 MAGEF1 Chr:3q13 NM_022149 Hs.306123 6.8 Above 2.1
59 218404_at sorting nexin 10 SNX10 Chr:7p15.2 NM_013322 Hs.418132 6.8 Above 2.8
60 203733_at dexamethasone-induced transcript DEXI Chr:16p13.2 NM_014015 Hs.157925 6.7 Above 2.9
61 213361_at tudor repeat associator with PCTAIRE 2 PCTAIRE2BP Chr:9q22.33 AW129593 Hs.416543 6.7 Above 2.1
62 201859_at proteoglycan 1, secretory granule PRG1 Chr:10q22.1 NM_002727 Hs.1908 6.7 Above 1.8
63 213622_at collagen, type IX, alpha 2 COL9A2 Chr:1p33-p32 AI733465 Hs.418012 6.7 Above 2.3
64 221692_s_at mitochondrial ribosomal protein L34 MRPL34 Chr:19p13.1 AB049652 Hs.238808 6.7 Above 1.6
65 207704_s_at growth arrest-specific 7 GAS7 Chr:17p NM_003644 Hs.226133 6.6 Above 2.5
66 201119_s_at cytochrome c oxidase subunit VIII COX8 Chr:11q12-q13 NM_004074 Hs.433901 6.6 Above 1.6
67 221036_s_at anterior pharynx defective 1B-like PSFL Chr:15q22.1 NM_031301 Hs.42954 6.6 Above 1.5
68 214259_s_at aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) AKR7A2 Chr:1p35.1-p36.23 AI144075 Hs.512807 6.6 Above 2.0
69 220057_at G antigen, family D, 2 GAGED2 Chr:Xp11.22-p11.21 NM_020411 Hs.112208 6.5 Above 17.3
70 203909_at solute carrier family 9 (sodium/hydrogen exchanger), isoform 6 SLC9A6 Chr:Xq26.3 NM_006359 Hs.62185 6.5 Above 1.4
71 210658_s_at golgi associated, gamma adaptin ear containing, ARF binding protein 2 GGA2 Chr:16p12 BC000284 Hs.133340 6.5 Above 2.1
72 202087_s_at cathepsin L CTSL Chr:9q21-q22 NM_001912 Hs.418123 6.5 Above 2.9
73 203562_at fasciculation and elongation protein zeta 1 (zygin I) FEZ1 Chr:11q24.2 NM_005103 Hs.79226 6.5 Above 4.6
74 201105_at lectin, galactoside-binding, soluble, 1 (galectin 1) LGALS1 Chr:22q13.1 NM_002305 Hs.407909 6.4 Above 2.5
75 214196_s_at ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease) CLN2 Chr:11p15 AA602532 Hs.429658 6.4 Above 2.1
76 210184_at integrin, alpha X (antigen CD11C (p150), alpha polypeptide) ITGAX Chr:16p11.2 M81695 Hs.385521 6.4 Above 2.9
77 220010_at potassium voltage-gated channel, Isk-related family, member 1-like KCNE1L Chr:Xq22.3 NM_012282 Hs.146372 6.4 Above 6.5
78 201152_s_at muscleblind-like (Drosophila) MBNL1 Chr:3q25 N31913 Hs.28578 6.3 Above 1.7
79 202592_at GCN5 general control of amino-acid synthesis 5-like 1 (yeast) GCN5L1 Chr:12q13-q14 NM_001487 Hs.94672 6.3 Above 1.5
80 221666_s_at apoptosis-associated speck-like protein containing a CARD ASC Chr:16p12-p11.2 BC004470 Hs.197875 6.3 Above 1.9
81 205936_s_at hexokinase 3 (white cell) HK3 Chr:5q35.2 NM_002115 Hs.411695 6.3 Above 5.7
82 202605_at glucuronidase, beta GUSB Chr:7q21.11 NM_000181 Hs.255230 6.3 Above 1.7
83 205859_at lymphocyte antigen 86 LY86 Chr:6p24.3 NM_004271 Hs.184018 6.3 Above 2.5
84 213908_at Homo sapiens hypothetical protein LOC339005, mRNA (cDNA clone IMAGE:4837016), partial cds --- --- AI824078 Hs.212670 6.3 Above 4.2
85 213844_at homeo box A5 HOXA5 Chr:7p15-p14 NM_019102 Hs.37034 6.2 Above 5.8
86 202180_s_at major vault protein MVP Chr:16p13.1-p11.2 NM_017458 Hs.80680 6.2 Above 2.0
87 209093_s_at glucosidase, beta; acid (includes glucosylceramidase) GBA Chr:1q21 K02920 Hs.511984 6.2 Above 1.5
88 200886_s_at phosphoglycerate mutase 1 (brain) PGAM1 Chr:10q25.3 NM_002629 Hs.447492 6.2 Above 1.8
89 220793_at sarcoma antigen SAGE Chr:Xq26 NM_018666 Hs.195292 6.2 Above 7.7
90 214651_s_at homeo box A9 HOXA9 Chr:7p15-p14 U41813 Hs.127428 6.2 Above 4.3
91 214730_s_at golgi apparatus protein 1 GLG1 Chr:16q22-q23 AK025457 Hs.78979 6.2 Above 1.6
92 221726_at ribosomal protein L22 RPL22 Chr:1p36.3-p36.2 BE250348 Hs.326249 -6.2 Below 1.7
93 211004_s_at aldehyde dehydrogenase 3 family, member B1 ALDH3B1 Chr:11q13 BC002553 Hs.274235 6.2 Above 1.8
94 217827_s_at acid cluster protein 33 ACP33 Chr:15q21-q22 NM_016630 Hs.242458 6.2 Above 1.6
95 204498_s_at adenylate cyclase 9 ADCY9 Chr:16p13.3 NM_001116 Hs.20196 6.1 Above 2.6
96 202897_at protein tyrosine phosphatase, non-receptor type substrate 1 PTPNS1 Chr:20p13 AB023430 Hs.156114 6.1 Above 2.1
97 207614_s_at cullin 1 CUL1 Chr:7q36.1 NM_003592 Hs.348153 -6.1 Below 2.0
98 218262_at hypothetical protein FLJ22318 FLJ22318 Chr:5q35.3 NM_022762 Hs.22753 6.1 Above 2.1
99 209367_at syntaxin binding protein 2 STXBP2 Chr:19p13.3-p13.2 AB002559 Hs.379204 6.1 Above 2.1
100 204174_at arachidonate 5-lipoxygenase-activating protein ALOX5AP Chr:13q12 NM_001629 Hs.100194 6.0 Above 3.1