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Supplementary Information

Identification of genes associated with chemotherapy cross-resistance and treatment response in childhood acute lymphoblastic leukemia.

Supplemental Table 9: Overlap in genes discriminating VCR-ASP discordant resistance and genes discriminating VCR- and ASP single-drug resistance.

Summary of the overlapping gene probe sets with corresponding gene symbol (GS), map location (ML) and ratio of expression in the unfavorable versus favorable group for VCR-ASP discordant resistance (Ratio). The ratio was calculated using the median log-transformed signal in VCR-sensitive plus ASP-resistant versus VCR-resistant plus ASP-sensitive (>1 is a gene probe set over-expressed in VCR-sensitive plus ASP-resistant ALL cells). A ratio of <1 is a gene probe set under-expressed probe sets in VCR-sensitive plus ASP-resistant ALL cells. The probe sets in overlap between VCR-ASP discordant resistance and single-drug resistance to ASP (A) and single-drug resistance to VCR (B) no overlap was found with PRD or DNR single-drug resistance. See also Supplemental Table 8D.

A
Probe Set ID Gene Name GS ML Ratio
203388_at arrestin, beta 2 ARRB2 17p13 0.54
202315_s_at breakpoint cluster region BCR 22q11.23 1.48
212886_at DKFZP434C171 protein DKFZP434C171 5q33.1 1.85
200705_s_at eukaryotic translation elongation factor 1 beta 2 EEF1B2 2q33-q34 1.52
200689_x_at eukaryotic translation elongation factor 1 gamma EEF1G 11q12.3 1.35
211927_x_at eukaryotic translation elongation factor 1 gamma EEF1G 11q12.3 1.27
210501_x_at eukaryotic translation initiation factor 3 subunit k eIF3k 19q13.2 1.33
200005_at eukaryotic translation initiation factor 3, subunit 7 zeta EIF3S7 22q13.1 1.36
221773_at ELK3, ETS-domain protein (SRF accessory protein 2) ELK3 12q23 0.44
211623_s_at fibrillarin FBL 19q13.1 1.40
220306_at FLJ20202 protein FLJ20202 1p12 1.84
209602_s_at GATA binding protein 3 GATA3 10p15 8.01
209604_s_at GATA binding protein 3 GATA3 10p15 2.74
217807_s_at glioma tumor suppressor candidate region gene 2 GLTSCR2 19q13.3 1.42
200651_at guanine nucleotide binding protein (G protein) GNB2L1 5q35.3 1.42
212070_at G protein-coupled receptor 56 GPR56 16q13 0.30
213828_x_at H3 histone, family 3A H3F3A 1q41 1.30
208755_x_at H3 histone, family 3A H3F3A 1q41 1.26
211940_x_at H3 histone, family 3A H3F3A 1q41 1.22
209806_at histone 1, H2be HIST1H2BE 6p21.3 0.58
201163_s_at insulin-like growth factor binding protein 7 IGFBP7 4q12 1.93
201015_s_at junction plakoglobin JUP 17q21 0.78
200010_at ribosomal protein L11 RPL11 1p36.1-p35 1.29
200715_x_at ribosomal protein L13a RPL13A 19q13.3 1.58
201217_x_at ribosomal protein L3 RPL3 22q13 1.58
215963_x_at ribosomal protein L3 RPL3 22q13 1.57
211666_x_at ribosomal protein L3 RPL3 22q13 1.54
211073_x_at ribosomal protein L3 RPL3 22q13 1.53
212039_x_at ribosomal protein L3 RPL3 22q13 1.50
200089_s_at ribosomal protein L4 RPL4 15q22 1.34
213080_x_at ribosomal protein L5 RPL5 1p22.1 1.37
200034_s_at ribosomal protein L6 RPL6 12q24.1 1.33
217740_x_at ribosomal protein L7a RPL7A 9q34 1.32
214167_s_at ribosomal protein, large, P0 RPLP0 12q24.2 1.57
208692_at ribosomal protein S3 RPS3 11q13.3-q13.5 1.28
200024_at ribosomal protein S5 RPS5 19q13.4 1.38
B
Probe Set ID Gene Name GS ML Ratio
219471_at chromosome 13 open reading frame 18 C13orf18 13q14.11 0.38
44790_s_at chromosome 13 open reading frame 18 C13orf18 13q14.11 0.38
217523_at CD44 antigen CD44 11p13 2.33
218642_s_at coiled-coil-helix-coiled-coil-helix domain containing 7 CHCHD7 8q11.23 0.63
218951_s_at hypothetical protein FLJ11323 FLJ11323 xp22.33; yp11.32 0.60
212492_s_at jumonji domain containing 2B JMJD2B 19p13.3 0.75
212956_at KIAA0882 protein KIAA0882 4q31.1 0.19
221011_s_at likely ortholog of mouse limb-bud and heart gene LBH 2p23.3 0.68
200088_x_at ribosomal protein L12 RPL12 9q34 1.29
200909_s_at ribosomal protein, large P2 RPLP2 11p15.5-p15.4 1.45
200031_s_at ribosomal protein S11 RPS11 19q13.3 1.24
213377_x_at ribosomal protein S12 RPS12 6q23.1 1.30
200781_s_at ribosomal protein S15a RPS15A 16p 1.27
212438_at putative nucleic acid binding protein RY-1 RY1 2p13.3 0.65
204849_at transcription factor-like 5 (basic helix-loop-helix) TCFL5 20q13.3-qter 0.15

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