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Supplementary Information

Identification of genes associated with chemotherapy cross-resistance and treatment response in childhood acute lymphoblastic leukemia.

Supplemental Table3 : Cross-validation using gene expression scores for cross-resistance and VCR-ASP discordant resistance.

Spearman's rank correlation (rho) and P-value for top probe sets discriminating cross-resistance and vincristine-asparaginase (VCR-ASP) discordant resistance are listed. In each iteration, based on 10-fold cross-validation, genes were reselected ( A ) or were not reselected ( B ).

  A B

 

Cross-resistance VCR-ASP discordance Cross-resistance VCR-ASP discordance
Probe sets rho P-value rho P-value rho P-value rho P-value
30 0.50 <0.0001 0.45 <0.0001 0.74 <0.0001 0.63 <0.0001
51 0.52 <0.0001 0.45 <0.0001 0.73 <0.0001 0.63 <0.0001
100 0.53 <0.0001 0.46 <0.0001 0.72 <0.0001 0.62 <0.0001
200 0.50 <0.0001 0.53 <0.0001 0.70 <0.0001 0.64 <0.0001

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