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Supplementary Information

Identification of genes associated with chemotherapy cross-resistance and treatment response in childhood acute lymphoblastic leukemia.

Supplemental Table 2 : False discovery rate.

False Discovery rate (FDR) was determined for the cross-resistance group and the vincristine plus asparaginase (VCR-ASP) discordant resistant group. Corresponding number of probe sets and Spearman's rank correlation P-value (a) are shown. FDR is lower and the number of gene probe sets is higher if the PCA score is based on the in vitro sensitivity data of 441 patients compared to using the PCA score based on the in vitro sensitivity data of only 129 patients.

  In vitro sensitivity of 441 patients In vitro sensitivity of 129 patients
  Cross-resistance VCR-ASP discordant resistance Cross-resistance VCR-ASP discordant resistance
a Probe Sets FDR [%] Probe sets FDR [%] Probe Sets FDR [%] Probe sets FDR [%]
0.00001 12 1.0 118 0.1 0 0 0 0
0.0001 51 2.8 229 0.6 4 23 4 16
0.001 170 8.0 496 2.9 32 40 32 40
0.01 480 20.6 1240 11.7 258 51 274 49

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