False Discovery rate (FDR) was determined for the cross-resistance group and the vincristine plus asparaginase (VCR-ASP) discordant resistant group. Corresponding number of probe sets and Spearman's rank correlation P-value (a) are shown. FDR is lower and the number of gene probe sets is higher if the PCA score is based on the in vitro sensitivity data of 441 patients compared to using the PCA score based on the in vitro sensitivity data of only 129 patients.
| In vitro sensitivity of 441 patients | In vitro sensitivity of 129 patients | |||||||
| Cross-resistance | VCR-ASP discordant resistance | Cross-resistance | VCR-ASP discordant resistance | |||||
| a | Probe Sets | FDR [%] | Probe sets | FDR [%] | Probe Sets | FDR [%] | Probe sets | FDR [%] |
| 0.00001 | 12 | 1.0 | 118 | 0.1 | 0 | 0 | 0 | 0 |
| 0.0001 | 51 | 2.8 | 229 | 0.6 | 4 | 23 | 4 | 16 |
| 0.001 | 170 | 8.0 | 496 | 2.9 | 32 | 40 | 32 | 40 |
| 0.01 | 480 | 20.6 | 1240 | 11.7 | 258 | 51 | 274 | 49 |