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Supplementary Information

Identification of genes associated with chemotherapy cross-resistance and treatment response in childhood acute lymphoblastic leukemia.

Supplemental Table 10: Proportional-hazards regression analysis.

Single factor proportional-hazards regression analysis of the risk of relapse in relation to known prognostic factors (i.e., white blood cell count (WBC), age at diagnosis) and cross-resistance and VCR-ASP discordant resistance gene expression scores are shown in Table (A) for COALL/DCOG patients and in Table (B) for St. Jude patients. Multiple proportional-hazards regression analysis of known prognostic factors (i.e., WBC, age) and gene expression scores are shown in Table (C) for COALL/DCOG patients and in Table (D) for St. Jude patients.

A B
Variable n HR 95% C.I. P-value n HR 95% C.I. P-value
Age
<10 years 96 1.0* 57 1.0*
>10 years 33 2.36 1.10-5.05 0.03 26 3.46 1.12-10.64 0.03
WBC
<49/nL 91 1.0* 50 1.0*
50-100/nL 20 0.88 0.26-3.03 0.84 16 3.05 0.76-12.2 0.12
>100/nL 18 3.82 1.69-8.67 0.0013 17 3.7 0.92-14.9 0.065
ALL subtype
B-other 42 1.0* 27 1.0*
BCR-ABL 5 2.49 0.72-8.64 0.15 8 11.65 2.50-54.0 0.0017
E2A-PBX1 6 0.93 0.21-4.07 0.92 12 0.76 0.08-6.83 0.81
Hyperdiploid 33 0.22 0.06-0.77 0.017 15 0.58 0.06-5.32 0.63
MLL-AF4 3 28.49 6.30-128.9 <0.0001 5 5.13 0.77-34.1 0.09
TEL-AML1 40 0.11 0.03-0.50 0.0038 16 0.57 0.06-5.33 0.63
GE score (CR)
Low+ 33 1.0* (8) ** ** **
Intermediate 63 2.31 0.65-8.18 0.2 73 1.0*
High‡ 33 5.99 1.7-21.09 0.0053 10 7.76 2.44-24.7 0.0005
GE score (VA)
Low+ 33 1.0* 16 1.0*
Intermediate 64 3.59 0.81-15.9 0.09 52 1.16 0.24-5.57 0.86
High‡ 32 9.04 2.04-40.1 0.0038 15 1.67 0.28-10.03 0.57
C D
Variable n HR 95% C.I. P-value n HR 95% C.I. P-value
Age
<10 years 96 1.0* 57 1.0*
>10 years 33 2.23 0.93-5.38 0.074 26 2.99 0.71-12.6 0.14
WBC
<49/nL 91 1.0* 50 1.0*
50-100/nL 20 0.98 0.27-3.5 0.98 16 4.70 1.0-22.1 0.05
>100/nL 18 5.06 2.05-12.5 0.0005 17 4.87 1.08-21.93 0.039
GE score CR
Low+ 33 1.0* (8) ** ** **
Intermediate 63 2.09 0.58-7.6 0.26 73 1.0*
High‡ 33 3.82 0.95-15.4 0.06 10 5.06 1.28-20.03 0.021
GE score VA
Low+ 33 1.0* 16 1.0*
Intermediate 64 2.76 0.61-12.47 0.19 52 0.36 0.06-2.24 0.27
High‡ 32 4.31 0.89-20.8 0.069 15 0.61 0.09-4.12 0.61

*reference group, **no relapses in this group, hazard ratio cannot be computed
‡top quartile; CR, cross-resistant ALL; VA, VCR-sensitive +ASP-resistant ALL
+bottom quartile; CR, cross-sensitive ALL; VA, VCR-resistant+ASP-sensitive ALL

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