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Supplementary Information

Identification of genes associated with chemotherapy cross-resistance and treatment response in childhood acute lymphoblastic leukemia.

Supplemental Figure 3: Distribution of LC50 values for each drug tested in the CR-group and VCR-ASP group analyzed for gene expression.

In each plot, the LC50 values (n=129) for each drug are plotted on the x-axis [prednisolone (PRD), vincristine (VCR) and daunorubicin (DNR) in g/ml; asparaginase (ASP) in IU/ml] and the percentage of patients in each range of LC50 values is plotted on the y-axis. A. The distribution of LC50 values for each drug; red indicates ALL classified based on CR-score as cross-resistant (n=29), gray as intermediate (n=62) and green as cross-sensitive (n=38). B. The distribution of LC50 values for VCR and ASP; blue indicates VCR-sensitive plus ASP-resistant ALL based on the VCR-ASP-score (n=42), orange indicates VCR-resistant plus ASP-sensitive ALL (n=34), and the remaining patients are indicated in gray (n=53).

Figure 3

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