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Supplementary Information

Identification of genes associated with chemotherapy cross-resistance and treatment response in childhood acute lymphoblastic leukemia.

Supplemental Figure 2: Distribution of cross-resistance (CR-scores) and VCR-ASP discordant resistance scores (VCR-ASP-scores) in B-lineage ALL patients.

Shown are the distributions of CR- and VCR-ASP scores among the 441 B-lineage ALL patients in the LC50 analysis (gray) and in the subgroup of 129 patients (in color) included in the gene expression analysis. The background is highlighted to indicate the LC50 values that define resistance (red) and sensitive (green) ALL for each drug (Pieters et al., 1990). A. Distribution of cross-resistant scores of the first component. Depicted in green are cross-sensitive ALL with low CR-scores (n=38), in yellow are ALL cells with intermediate CR-scores (n=62) and in red cross-resistant ALL with high CR-scores (n=29). B. Distribution of VCR-ASP-scores of the second component. Depicted in blue VCR-sensitive plus ASP-resistant ALL with high VCR-ASP-scores (n=42), in yellow ALL that does not exhibit discordant sensitivity to ASP and VCR with intermediate VCR-ASP-scores (n=53) and in orange are VCR resistant plus ASP sensitive ALL with low VCR-ASP-scores (n=34).

Figure 2

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