Unsupervised hierarchical clustering of 173 patients was performed using 14,550 probe sets. Age (red= >10 years), white blood cell count (WBC, red= >100 x109/L), genetic or lineage subtype (see legend) and the combined drug resistance gene expression (GE) score for prednisolone, vincristine, asparaginase and daunorubicin are shown for each patient (high/resistant in red= GE score>5.58 and low/sensitive green= GE score<4.70). Unsupervised clustering is largely driven by ALL subtype, e.g., T- and B-lineage ALL. None of the other known prognostic features (patient age, WBC) clustered in an unsupervised analysis, as was also the case for the drug resistance gene expression score.
< Table of Content | Next Figure >