Member, St. Jude Faculty
Director, Molecular Clinical Trials Core
Co-Leader, Neurobiology & Brain Tumor Program
St. Jude Children's Research Hospital
See Faculty Bio
Investigators at St. Jude Children's Research Hospital and collaborating sites have performed a large scale project interrogating genomic alterations in ependymoma using a variety of complementary approaches. These include examination of DNA copy number alterations and loss of heterozygosity using single nucleotide polymorphism arrays; gene expression profiling; and miRNA expression profiling. These data are part of a primary publication in Nature: Johnson et al., "Cross species genomics matches mutations and cell compartments to model ependymoma." Due to privacy concerns, the primary SNP array data is not available with unrestricted access. Individuals wishing to obtain this data for research purposes may request access using the link below.
Link to Brain Tumor Genomic Data
Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations.
Margaret C. Thompson, Christine Fuller, Twala L. Hogg, James Dalton, David Finkelstein, Ching C. Lau, Murali Chintagumpala, Adekunle Adesina, David M. Ashley, Stewart J. Kellie, Michael D. Taylor, Tom Curran, Amar Gajjar, and Richard J. Gilbertson
J Clin Oncol 2006 Apr 20;24(12):1924-31.
Radial glia cells are candidate stem cells of ependymoma.
Michael D. Taylor, Helen Poppleton, Christine Fuller, Xiaoping Su, Yongxing Liu, Patricia Jensen, Susan Magdaleno, James Dalton, Christopher Calabrese, Julian Board, Tobey MacDonald, Jim Rutka, Abhijit Guha, Amar Gajjar, Tom Curran, and Richard J. Gilbertson
Cancer Cell 2005 Oct;8(4):323-35.