Supplementary Files for Guiguemde et al, Nature, 2010
Scientists release data on potential new treatment targets for malaria An international team led by St. Jude Children's Research Hospital investigators released data detailing the effectiveness of nearly 310,000 chemicals against a malaria parasite that remains one of the world's leading killers of young children. The research, which appears in the May 20 edition of the scientific journal Nature, identified more than 1,100 new compounds with confirmed activity against the malaria parasite. Of those, 172 were studied in detail; leading to identification of almost two dozen families of molecules investigators consider possible candidates for drug development.
Below are links to files that are supplementary to the Nature paper.
High resolution pdfs of manuscript figures:
Cytoscape file containing the chemical structure network graph: Cytoscape .cys file
Summary of all experimental data for 1536 compounds reported in this manuscript:
Summary of the primary screen (309474 screening compounds, 372480 total records including controls, reference compounds, and blank wells):