Research in the Guy laboratory focuses on two main areas: assembly of the transcriptional activation complex by nuclear hormone receptors, especially the thyroid, androgen, and glucocorticoid receptors; and, the development of novel therapeutic agents for pediatric orphan diseases, especially malaria, retinoblastoma, ependymoma, and sleeping sickness. Our major technique focuses are parallel synthetic and medicinal chemistry, high content screening, and high throughput screening.