Sepsis-associated neuronal damage: development of a model, induction by intravascular bacterial cell wall and attenuation by CDP-choline

Carlos Orihuela ^1,4, Sophie Fillon ^1,4, S. Hope Smith-Sielicki ¹, Waleed Gaber ², Christopher Guglielmo¹, Geli Gao ¹, Konstantinos Soulis ¹, Avinash Patil ³, Peter J. Murray ¹, and Elaine I. Tuomanen ¹

¹ Department of Infectious Diseases, St. Jude Children’s Research Hospital , 332 N. Lauderdale Rd , Memphis , TN , 38105
² Department of Health Science Engineering, University of Memphis , Central Ave. , Memphis , TN , 38163
³ University of Tennessee Medical School , Dunlap Ave. , Memphis , TN , 38163
⁴ These authors contributed equally to this work.