Comparative genomic analysis of Streptococcus pneumoniae clinical isolates: Identification of genes contributing to invasive pneumococcal disease

Caroline A. Obert 1,5 , Jack Sublett 1,5 , Deepak Kaushal 2 , Geli Gao 1 , Theresa Barton 3 , Jessica Kennedy 4 , Elaine I. Tuomanen 1 , and Carlos J. Orihuela 1

1 Department of Infectious Diseases, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105

2 Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105

3 Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390.

4 College of Graduate Health Sciences, The University of Tennessee Health Science Center , 62 S. Dunlap, Suite 420 , Memphis , TN 38163

5 contributed equally to this work