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Eng-Juh Yeoh, Mary E. Ross, Shelia A. Shurtleff, W. Kent Williams, Divyen Patel, Rami Mahfouz, Fred G. Behm, Susana C. Raimondi, Mary V. Relling, Anami Patel, Cheng Cheng, Dario Campana, Dawn Wilkins, Xiaodong Zhou, Jinyan Li, Huiqing Liu, Ching-Hon Pui, William E. Evans, Clayton NAeve, Limsoon Wong, James R. Downing

Additional Supplemental Data added March 4, 2004 can be downloaded at
the following link: March 4, 2004 Additional Data

Section I: Expanded Methods
  A. RNA extraction procedure, labeling, hybridization, and data analysis
  B. Reproducibility of microarray data
  C. Comparison of microarray data between PB and BM leukemic samples
  D. Real-time RT-PCR results
  E. Comparison of real-time RT-PCR and Affymetrix data
  F. Comparison of Affymetrix and immunophenotype results

Section II: Patient Dataset

Section III: Detailed Analysis
   A. Hierarchical cluster analysis of diagnostic cases using genes that passed the variation filter
   B. Methods for gene selection
   C. Chi-square
   D. Correlation-based Feature Selection (CFS)
   E. T-statistics
   F. Wilkins'
   G. SOM/DAV
   H. Comparison of genes selected by the different metrics
   I. Decision tree for the diagnosis of genetic subtypes
   J. Description of supervised learning algorithms
   K. Support Vector Machine (SVM)
   L. Prediction by Collective Likelihood of Emerging Patterns (PCL)
   M. K-Nearest Neighbors (K-NN)
   N. Artificial Neural Networks (ANN)
   O. Table of results using the different algorithms to predict genetic subgroups
   P. Absence of correlation of expression data for genetic subtypes with stage of B-cell differentiation
   Q. Results for relapse prediction
   R. Permutations test results
   S. Results for secondary AML prediction
   T. FISH analysis
   U. References

ALL6: Expression of the outcome predictor in acute leukemia 1 (OPAL1) gene is not an independent prognostic factor in patients treated according to COALL or St Jude protocols. (Added December 2006)